Evidence map›Paper›PMID 39920829›Full record

ArticleAntimicrobial resistance and infection control2025

The antibiotic procurement saga: a long-neglected stewardship target to combat antimicrobial resistance in Pakistan.

Shairyar Afzal, Mishal Bajwa, Nabeel Ahmed, Jawaria Jabeen, Mian Shahzeb Haroon, Rana Muhammad Zahid Mushtaq, Zikria Saleem

Abstract read
In one paragraph

Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shairyar AfzalDepartment of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Islamabad Campus, Islamabad, Pakistan.ORCID 0009-0008-8733-1748
Mishal BajwaDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan. mishalbajwa17@yahoo.com.ORCID 0000-0002-9601-2692
Nabeel AhmedCollege of Pharmacy, University of Sargodha, Sargodha, Pakistan.ORCID 0009-0009-7550-213X
Jawaria JabeenCollege of Pharmacy, University of Sargodha, Sargodha, Pakistan.ORCID 0009-0009-4300-0442
Mian Shahzeb HaroonDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.ORCID 0009-0004-8531-8081
Rana Muhammad Zahid MushtaqInstitute for Regeneration and Repair (IRR), Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8277-0177
Zikria SaleemFaculty of Pharmacy, Bahauddin Zakariya University, Multan, Punjab, 60800, Pakistan. xikria@gmail.com.ORCID 0000-0003-3202-6347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConsistent and timely access to antibiotics is a hallmark of an antimicrobial stewardship program (ASP) and can be achieved through good procurement practices. However, flawed procurement modules result in poor antibiotic supply management within health facilities of low- and middle-income countries (LMICs), including Pakistan, exacerbating antimicrobial resistance (AMR). This study seeks to understand hospital pharmacists' perspectives on the antibiotic procurement process, its efficiency in ensuring consistent access to antibiotics, and the role of clinical pharmacists in rational procurement.

methodsSemi-structured interviews with 24 purposively selected hospital pharmacists from secondary healthcare facilities in Punjab, Pakistan, were conducted utilizing a qualitative case study methodology. Data analysis was conducted using MAXQDA 2024 software, following a thematic analysis technique using a codebook approach to thematic analysis.

resultsThe study identified five central themes: (1) The state of antibiotic use in hospitals is characterized by a lack of antibiotic use policy, resulting in mostly empirical and irrational prescribing practices. (2) Medicine availability significantly influences prescribing decisions, often taking precedence over clinical needs. (3) The procurement process, although structured, is flawed owing to rigid adherence to the Standard Medicine List (SML). (4) Rationality in procurement is compromised by disregard for AMR, with decisions driven more by cost and demand than clinical evidence. (5) The clinical acumen of pharmacists is underutilized in procurement due to multifarious barriers.

conclusionAntibiotic procurement is the mainstay of implementing an ASP in hospitals. This study elucidates significant policy, practice, and education gaps regarding antibiotic use and procurement in Pakistan. There is a critical need for comprehensive antibiotic policies, including a revision in SML, enhancing pharmacist authority in procurement decisions, more rational prescribing, and ensuring access to antibiotics through more informed and data-driven processes to combat AMR effectively.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipDrug Resistance, BacterialPharmacistsHealth PolicyHumansInterviews as TopicPakistanPharmacy Service, HospitalAnti-Bacterial AgentsAntibiotic accessAntibiotic procurementAntibiotic use policyAntimicrobial resistance (AMR)Antimicrobial stewardship program (ASP)Clinical pharmacist

Identifiers

PMID39920829
PMCPMC11806573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.