Evidence map›Paper›PMID 39920714›Full record

Observational studyAIDS research and therapy2025

Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making.

Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan and 8 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carlo SacdalanSEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand. carlo.s@searchthailand.org.
Curtis AustinWashington University School of Medicine in St. Louis, St. Louis, MO, USA.
Aswathy VarmaMedicine and Surgery, University of Milan, Milan, Italy.
Suteeraporn PinyakornUnited States Military HIV Research Program; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Eugène KroonSEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand.
Donn J ColbyUnited States Military HIV Research Program; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Phillip ChanDepartment of Neurology, Yale University, New Haven, CT, USA.
Orlanda GohSEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand.
Krittaporn PornpaisakulSEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand.
Jintana IntasanSEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand.
Tassanee LuekasemsukSEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand.
Merlin L RobbUnited States Military HIV Research Program; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nitiya ChomcheySEARCH Research Foundation, Block 28, 926 Tower C, Room C114-C115, Soi Chula 7, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand.
Nittaya PhanuphakInstitute of HIV Research and Innovation, Bangkok, Thailand.
Jintanat AnanworanichAmsterdam UMC, Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.
Sandhya VasanUnited States Military HIV Research Program; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Denise HsuUnited States Military HIV Research Program; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
SEARCH 010/RV254 study group

Funding

Impact of IL-15 immunotherapy on tissue-specific CD8 T cells to reduce the CNS HIV reservoir seeding and persistenceR01MH130197 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Lishomwa C Ndhlovu, Afamefuna Okoye · 2022 to 2026
$5.1M
Henry M. Jackson Foundation W81XWH-18-2-0040NIH HHS R01MH130197NIMH NIH HHS R01 MH130197
6 · The paper itself

Abstract

introductionData about impact of switch to dolutegravir (DTG)-based antiretroviral therapy (ART) on estimated glomerular filtration rate (eGFR) in Asians are scarce. RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART.

methodsParticipants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61-145). GFR was estimated by serum creatinine (eGFR

resultsAt study entry, 20 participants (9.3%) had eGFR

conclusionsPersistent eGFR

Indexed as

Anti-HIV AgentsClinical Decision-MakingCreatinineCystatin CGlomerular Filtration RateHeterocyclic Compounds, 3-RingHIV InfectionsHIV Integrase InhibitorsAdultAlkynesBenzoxazinesCyclopropanesDolutegravirDrug SubstitutionFemaleHumansAlkynesAnti-HIV AgentsBenzoxazinesCreatinineCyclopropanesCystatin CDolutegravirefavirenzHeterocyclic Compounds, 3-RingHIV Integrase InhibitorsOxazinesPiperazinesPyridonesCreatinineCystatin CDolutegravirGlomerular filtration rateHIV infectionRenal insufficiency

Identifiers

PMID39920714
PMCPMC11804080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.