ArticleCardiovascular diabetology2025
The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between the triglyceride-glucose index and diabetic peripheral neuropathy: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Anthropometry-adjusted TyG indices predict diabetes, graft failure, and mortality in kidney transplant recipients.Journal of the Endocrine Society · 2026Article
- Observational
- Association of the C-reactive protein-triglyceride glucose index with all-cause and cardiovascular mortality among U.S. adults with metabolic dysfunction-associated steatotic liver disease: a national cohort study.Cardiovascular diabetology · 2026Article
- Dynamic association between triglyceride-glucose-body mass index and hospital mortality in critically ill patients with heart failure: a multicenter retrospective cohort study.Cardiovascular diabetology · 2026Observational
- A Cross-Sectional Study Based on Deep Learning to Explore the Effect of Triglyceride/Glucose Index on Periodontitis: An Analysis Based on the Large NHANES Database.Oral health & preventive dentistry · 2026Article
- Association of the triglyceride glucose-Chinese visceral adiposity index with incident cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between systemic inflammatory response index and cardiovascular disease risk in rheumatoid arthritis patients: a machine learning based on US and Chinese cohorts.Clinical rheumatology · 2026Article
- Prospective associations of triglyceride-glucose related indices with cardiovascular disease and mortality in individuals with metabolic syndrome: evidence from the UK biobank.Cardiovascular diabetology · 2026Article
- Association of triglyceride glucose index and volumetric bone mineral density in T2DM: fat distribution as a potential indirect link.Frontiers in cell and developmental biology · 2026Article
- Cross-sectional associations of metabolic risk indices and cardiometabolic multimorbidity among adults with depressive symptoms: evidence from China and the United Kingdom.Archives of medical science : AMS · 2026Article
- Thiazide Diuretics Are Associated with a Higher Triglyceride-Glucose Index Than Calcium Channel Blockers in Hypertensive Patients.International journal of general medicine · 2026Article
- Plasma ceramide Cer24:0 and insulin resistance: associations with TyG and TG/HDL-C in a multicenter study of coronary artery disease cohorts.Frontiers in endocrinology · 2026Observational
- Summary of the best evidence for non-pharmacological interventions for dyslipidemia in patients with coronary heart disease.Frontiers in cardiovascular medicine · 2026Review
- Joint association of triglyceride glucose index and relative fat mass with new-onset cardiovascular events: a prospective study from CHARLS.Lipids in health and disease · 2025Article
- Diabetes modifies the association between the triglyceride-glucose index and subclinical myocardial injury: A prospective cohort study.Cardiovascular diabetology · 2025Article
- Estimated glucose disposal rate and the dynamic transitions of cardiometabolic multimorbidity and all-cause mortality in prediabetes: a multistate trajectory analysis.Lipids in health and disease · 2025Article
- Effect of changes in the triglyceride-glucose index on atherogenic lipid profiles in coronary artery disease patients receiving lipid-lowering therapy: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Development and validation of a novel nomogram to predict coronary artery calcification: a single center study.European journal of medical research · 2025Article
- Combined association of triglyceride-glucose index and systemic inflammation index on all-cause and cardiovascular mortality.Scientific reports · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe triglyceride-glucose (TyG) index is recognized as an alternative measure of insulin resistance (IR) and has been linked to the risks of cardiovascular disease (CVD) and mortality. This study aimed to evaluate whether the association between the TyG index and CVD mortality is influenced by the use of antidiabetic and hypolipidemic agents, given their potential modifying effects on the TyG index.
methodsParticipants from the National Health and Nutrition Examination Survey (1999-2018) were included in the study. Mortality outcomes were tracked through linkage with National Death Index records until December 31, 2019. Data on the use of antidiabetic and hypolipidemic medications (including prescribed insulin, diabetic pills, and cholesterol-lowering agents) were self-reported by participants.
resultsA total of 5,046 adults (representing 42,753,806 individuals, weighted mean age 61.08 years [SE: 0.24]; 49.35% female) were analyzed. The TyG index was significantly associated with all-cause and CVD mortality, and these associations were modified by the use of antidiabetic and hypolipidemic agents (p < 0.01). Significant interactions were observed between the TyG index and the use of these agents for mortality outcomes after full adjustments (p-value for interaction < 0.05). Exposure-effect analysis revealed a U-shaped relationship between TyG index levels and the risks of all-cause and CVD mortality in participants using these agents, while a linear positive relationship was observed in participants not using these agents.
conclusionsThe use of antidiabetic and hypolipidemic agents modify the association between the TyG index and all-cause and CVD mortality. These findings suggest that future studies on the TyG index and its relationship with CVD and mortality should account for the modifying effects of these agents.
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