ArticleBMC infectious diseases2025
Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Tick-Tac-Foe: When Ticks, Trade, and Zoonotic Pathogens Align in African Wet Meat Markets.Public health challenges · 2026Review
- Targeted next-generation sequencing improves diagnosis and antimicrobial stewardship in Chlamydia psittaci pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Next-Generation Sequencing Dataset Downloader and In Silico Sequence Mining: Graphical-User-Interface-Based Tools for Accessible, Multiprobe Target Mining in Next-Generation Sequencing Data.Computational and structural biotechnology journal · 2026Article
- AcuteFrontiers in medicine · 2026Article
- Clinical features of Q fever vertebral osteomyelitis: case reports and literature review.Frontiers in medicine · 2026Article
- Q Fever-Related Community Infections: United States Exposure toPathogens (Basel, Switzerland) · 2025Article
- Correction: Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii.BMC infectious diseases · 2025Article
- Omadacycline in the treatment of severe Q fever pneumonia during an influenza epidemic: a case report with literature review.Frontiers in medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
purposeQ fever is a zoonotic bacterial disease caused by Coxiella burnetii. Due to its variable and non-specific clinical symptoms, the disease is often overlooked and underreported. To date, the identification of C. burnetii as the causative pathogen of Q fever using targeted next-generation sequencing (tNGS) has not been previously documented.
methodstNGS was performed on patients with acute fever of unknown etiology, and qPCR was confirmed for C. burnetii infection.
resultstNGS was performed on 112 patients with acute fever of unknown etiology at Peking University Third Hospital between March 27 and September 20, 2024. C. burnetii was identified in blood samples from five patients, leading to a clinical diagnosis of Q fever. These diagnoses were subsequently confirmed by qPCR at the Beijing CDC. The mean age of the patients was 39.6 years (range: 32-59 years). Although blood cultures were negative, elevated infection markers (CRP, PCT, and ferritin) and liver enzymes (ALT, AST, GGT, ALP, and LDH) were observed. No epidemiological links to Q fever were identified in these cases. All five patients were treated promptly with oral doxycycline (0.1 g twice daily for 2 weeks) and discharged in improved health.
conclusionstNGS is a promising and significant tool for rapidly detecting C. burnetii infection.
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