ReviewJournal of agricultural and food chemistry2025
Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects.
Review in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- From rhizosphere to gut: microbial drivers of tea flavor and bioactivity.NPJ science of food · 2026Article
- Epigallocatechin Gallate From Tea Delays Oocyte Aging After Ovulation in Mice.Food science & nutrition · 2026Article
- Natural products targeting cytokine-regulated SASP inflammation networks in Ovarian cancer: Implications on immune escape and molecular resistance.Inflammopharmacology · 2026Review
- A Review ofFoods (Basel, Switzerland) · 2026Review
- Phenolic Acids and Their Derivatives in Tea: Chemical Diversity, Processing Changes, Sensory Contributions, and Health Implications-A Comprehensive Review.Comprehensive reviews in food science and food safety · 2026Review
- Rewiring NADH Metabolism Through NQO1-Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tea polyphenols suppress the malignant progression of renal cancer cells by targeting Nosip.Translational andrology and urology · 2026Article
- Monitoring Antioxidant Preservation in Microwave-Dried Tea Using HFoods (Basel, Switzerland) · 2026Article
- Binding of epigallocatechin-3-gallate to myoglobin attenuated hemin release and lipid peroxidation: New insight into the antioxidant mechanism.Current research in food science · 2026Article
- Sensory signaling mediates the systemic metabolic and neurological effects of epigallocatechin gallate.Frontiers in nutrition · 2026Article
- Epigallocatechin-3-gallate supplementation regulates glucose redistribution through its potential endogenous receptor in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- FBXO5 drives hepatocellular carcinoma progression and is a target for tea polyphenol-mediated inhibition.Translational cancer research · 2025Article
- Discovery of Gingipains andFoods (Basel, Switzerland) · 2025Review
- A Comprehensive Review of Theaflavins: Physiological Activities, Synthesis Techniques, and Future Challenges.Food science & nutrition · 2025Review
- Investigation of the regulatory effects of tea polyphenols on CYP450s in HepG2 cells.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tea polyphenols (TPP) are key contributors to the beneficial health effects of green tea and black tea. However, their molecular mechanisms of action remain unclear. This article discusses the importance of the bioavailability of TPP in understanding their mechanisms of action and health effects of tea consumption. The systemic bioavailability is rather high for smaller catechins, low for galloyl catechins, and very low or null for oligomers and polymers from black tea. The bioavailability of TPP oxidation-derived polymers and self-assembled nanomaterials is not clearly known. If the large molecular weight TPP cannot get into systemic circulation, then the biological activities and mechanisms of action derived from studies in vitro are unlikely to be relevant to their actions in internal organs in vivo. In that case, their interactions with microbiota and actions on the epithelial cells of the gastrointestinal tract are important to their health effects. Therefore, the bioavailability of different types of TPP is an important factor in determining their mechanisms of action and the health effects of tea consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.