Evidence map›Paper›PMID 39920561›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Thioridazine Induces Increase in Expression of the Pyruvate Transporter MPC1 Associated with Immune Infiltration in Malignant Tumors.

E A Bogomolova, M M Murashko, E M Stasevich, A N Uvarova, E A Zheremyan, K V Korneev, D V Kuprash, D E Demin

Abstract read
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In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E A BogomolovaLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia. elvina.elochka@gmail.com.ORCID https://orcid.org/0009-0009-9407-613X
M M MurashkoLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID https://orcid.org/0000-0001-7235-5052
E M StasevichLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID https://orcid.org/0000-0003-2150-9458
A N UvarovaLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID https://orcid.org/0000-0002-3168-6872
E A ZheremyanLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID https://orcid.org/0000-0002-1230-6168
K V KorneevLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID https://orcid.org/0000-0003-3570-8327
D V KuprashLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID https://orcid.org/0000-0002-1488-4148
D E DeminLaboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia. denisdeminbio@gmail.com.ORCID https://orcid.org/0000-0002-5553-6588

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The MPC1 gene is involved in the transport of pyruvate into mitochondria, playing an important role in metabolic processes. Recently, it has been reported that higher MPC1 expression correlates with an increased number of immune cells in human cervical and lung cancers, indicating an enhanced antitumor immune response. Reduced MPC1 levels in gastric tumors are associated with a more severe disease course. Correlational analysis of the MPC1 gene in human lung, hippocampus and frontal cortex tissue samples based on data from the GTEx database revealed associations of this gene with schizophrenia, non-small cell lung cancer, and immune diseases. Our experiments showed that the mRNA level of the MPC1 gene in the non-small cell lung cancer cell line A549 increases 5-fold under the influence of the schizophrenia neuroleptic thioridazine. The observed elevation of MPC1 level may cause tumor infiltration by immune cells, complementing the previously reported data indicating the ability of thioridazine to slow cell growth, induce apoptosis and reduce the ability of cells to migrate.

Indexed as

Carcinoma, Non-Small-Cell LungGene Expression Regulation, NeoplasticLung NeoplasmsMitochondrial Membrane Transport ProteinsThioridazineA549 CellsCell Line, TumorHumansMonocarboxylic Acid TransportersMitochondrial Membrane Transport ProteinsMonocarboxylic Acid TransportersMPC1 protein, humanThioridazineimmune infiltrationMPC1non-small cell lung cancerschizophreniathioridazine

Identifiers

PMID39920561
PMCPMC12050224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.