Evidence map›Paper›PMID 39920553›Full record

ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2025

Association of asparagine in saliva with a lower risk of early childhood caries in undernourished children: a cross-sectional study.

P H M Lima, A C M Mota, V Lima, G P Cidrao, D O Toyama, M H Toyama, C S Fonteles

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Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Asparagine in saliva with a lower risk of early childhood caries in undernourished children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

P H M LimaPostgraduate Program in Dentistry, Federal University of Ceara, UFC, Fortaleza, Brazil.ORCID http://orcid.org/0000-0003-1939-1219
A C M MotaPostgraduate Program in Dentistry, Federal University of Ceara, UFC, Fortaleza, Brazil.ORCID http://orcid.org/0000-0003-1349-6204
V LimaPostgraduate Program in Dentistry, Federal University of Ceara, UFC, Fortaleza, Brazil.ORCID http://orcid.org/0000-0002-8652-4133
G P CidraoDepartment of Clinical Dentistry, Federal University of Ceara, UFC, Fortaleza, Brazil.ORCID http://orcid.org/0000-0001-7963-7407
D O ToyamaInstitute of Biosciences, São Paulo State University, São Vicente, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1911-4337
M H ToyamaInstitute of Biosciences, São Paulo State University, São Vicente, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6836-3084
C S FontelesUT Health School of Dentistry, 7500 Cambridge St., Suite 5306, Houston, TX, 77054, USA. cristiane.s.fonteles@uth.tmc.edu.ORCID http://orcid.org/0000-0003-4197-6002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim was to investigate the salivary amino acid profile in children with protein-energy undernutrition (PEU) and its association with caries experience in the presence of other risk factors.

methodsThe study had a cross-sectional design and was carried out with 122 children (12-71 months old), classified according to their level of undernutrition (mild-GI, n = 22; moderate-GII, n = 53) or healthy controls (GC, n = 47). The children were categorized based on the presence of caries into caries-experienced groups (ceos > 0, 22 CG, 12 GI and 18 GII) and caries-free groups (ceos = 0, 25 CG, 10 GI and 36 GII). Total unstimulated and stimulated saliva were collected to determine amino acids and Streptococcus mutans, respectively.

resultsEighteen amino acids were associated with PEU. Undernutrition and caries experience influenced the presence of the following amino acids: L-anserine, asparagine, ethanolamine, gamma-aminobutyric acid, and norleucine. Asparagine was a significant predictor of a lower probability of caries experience in a logistic regression model.

conclusionsSalivary amino acids are associated with undernutrition in children, and the presence of asparagine in saliva relates to a lower caries risk.

Indexed as

AsparagineDental CariesProtein-Energy MalnutritionSalivaChild, PreschoolCross-Sectional StudiesDMF IndexFemaleHumansInfantMaleRisk FactorsStreptococcus mutansAsparagineAmino AcidsCariesChild Nutrition DisordersProtein Energy MalnutritionSaliva

Identifiers

PMID39920553

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.