Evidence map›Paper›PMID 39920477›Full record

ReviewBiogerontology2025

Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity.

Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Sana Sadatipour, Ghazalnaz Baghdadi, Dorsa Jalaei, Safa Tahmasebi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mehran IzadiDepartment of Infectious and Tropical Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nariman SadriSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Amirhossein AbdiSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Mohammad Mahdi Raeis ZadehSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Sana SadatipourSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Ghazalnaz BaghdadiSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Dorsa JalaeiSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Safa TahmasebiSynapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran. Safa.tahmasebi@sbmu.ac.ir.ORCID 0000-0002-8598-1922

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a complex and heterogeneous biological process characterized by telomere attrition, genomic instability, mitochondrial dysfunction, and disruption in nutrient sensing. Besides contributing to the progression of cancer, metabolic disorders, and neurodegenerative diseases, these manifestations of aging also adversely affect organ function. It is crucial to understand these mechanisms and identify interventions to modulate them to promote healthy aging and prevent age-related diseases. Vitamins have emerged as potential modulators of aging beyond their traditional roles in health maintenance. There is an increasing body of evidence that hormetic effects of vitamins are responsible for activating cellular stress responses, repair mechanisms, and homeostatic processes when mild stress is induced by certain vitamins. It is evident from this dual role that vitamins play a significant role in preventing frailty, promoting resilience, and mitigating age-related cellular damage. Moreover, addressing vitamin deficiencies in the elderly could have a significant impact on slowing aging and extending life expectancy. A review of recent advances in the role of vitamins in delaying aging processes and promoting multiorgan health is presented in this article. The purpose of this paper is to provide a comprehensive framework for using vitamins as strategic tools for fostering longevity and vitality. It offers a fresh perspective on vitamins' role in aging research by bridging biological mechanisms and clinical opportunities.

Indexed as

AgingAntioxidantsLongevityVitaminsAnimalsHumansOxidative StressAntioxidantsVitaminsAgingEpigeneticImmune systemLongevityOxidative stressVitamin

Identifiers

PMID39920477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.