SynthesisNeurosurgical review2025
Are EGFR monoclonal antibodies associated with clinical benefits in patients with glioma: a systematic review, meta-analysis, and specific analysis on glioblastoma and diffuse intrinsic pontine glioma.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- ErbB signaling in brain injury regeneration: Pathway interactions and therapeutic potential.Neural regeneration research · 2026Article
- Antibody therapies in glioblastoma: Overcoming micro-environmental barriers.Iranian journal of basic medical sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioma is one of the most common CNS malignancies with a high mortality rate. Overexpression of endothelial growth factor receptor (EGFR) has been suspected to play a critical role in the pathology of gliomas. This study aims to investigate the effectiveness of anti-EGFR monoclonal antibodies against glioma, specifically for glioblastoma and diffuse intrinsic pontine glioma. This Systematic review and meta-analysis was conducted according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search used the relevant keywords in four databases, including PubMed, Scopus, Web of Science, and Embase, until December 25th, 2023. All statistical analysis was done by STATA v.17. A total of 29 studies were included. A meta-analysis revealed that overall response was 34% (95%CI: 19-51%), complete response was 14% (95%CI: 3-24%), partial response was 13% (95% CI: 8-17%), progressive disease rate was 33% (95%CI: 24-43%), and stable disease rate was 29% (95%CI: 22-36%). In addition, the pooled 6-month progression-free survival (PFS) rate was 48% (95% CI: 33-62%), 1-year PFS was 25% (95%CI: 14-36%), 18-month PFS was 17% (95%CI: -5-39%), and 2-year PFS was 14% (95%CI: 3-25%). The 6-month overall survival (OS) was 82% (95%CI: 69-96%), 1-year OS was 61% (95%CI: 50-71%), 18-months OS was 39% (95%CI: 25 - 53%), and 2-year OS was 24% (95%CI: 15-33%). EGFR inhibitors benefit PFS, OS, and radiologic response in patients with different types of gliomas. Clinicians should consider them an attractive option for treating gliomas.
Indexed as
Identifiers
39920453What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.