Evidence map›Paper›PMID 39920425›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Prehabilitation to improve function after autologous stem cell transplantation: A pilot randomized controlled trial (PIRATE).

Amy M Dennett, Judi Porter, Stephen B Ting, Nicholas F Taylor

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07066592 (Investigation of the Effects of Prehabilitation Education Delivered Through a Mobile Compatible Website on Quality of Life and Symptoms in Patients Undergoing Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07066592 naactive not recruitingnot on this map

Investigation of the Effects of Prehabilitation Education Delivered Through a Mobile Compatible Website on Quality of Life and Symptoms in Patients Undergoing Hematopoietic Stem Cell Transplantation

TypeinterventionalSponsorSaglik Bilimleri UniversitesiRan2024 to 2025Enrolled36ConditionsHematological Malignancy, Prehabilitation, Patient EducationArmsPrehabilitation education provided via mobile compatible website
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A trifold prehabilitation model prior to induction chemotherapy in patients with leukemia: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy M DennettSchool of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Australia. amy.dennett@easternhealth.org.au.
Judi PorterInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Stephen B TingDepartment of Clinical Haematology, Eastern Health, Box Hill, Australia.
Nicholas F TaylorSchool of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExercise and nutrition interventions are not part of routine care for those undergoing autologous stem cell transplant (autoSCT). We aimed to explore estimates of effect, safety and feasibility of multidisciplinary prehabilitation for improving physical capacity after autoSCT.

methodsThis single-blinded, parallel, two-armed pilot randomized trial included adults receiving autoSCT. Participants were randomized to twice-weekly, supervised, tailored exercise and fortnightly telephone-based nutrition education, for up to 8-weeks prior to autoSCT (n = 11) or usual care (n = 11). Blinded assessments occurred at baseline (T0), pre-transplant (T1), and 4-weeks post-transplant (T2). The primary outcome was physical capacity (6-min walk test). Secondary measures included recruitment rate, adverse events, exercise adherence, physical status, nutritional status, health-related quality of life, and health service outcomes.

resultsPositive estimates of effect for walking capacity in favour of the experimental group were demonstrated at T2 (MD + 141 m, 95% CI 24 to 257 m). There was high recruitment (81%) and adherence and no major adverse events. At T2 there were large estimates of effect favoring the experimental group for higher bodyweight, and less dyspnea and gastrointenstinal symptoms. There were no between-group differences in other outcomes.

conclusionPrehabilitation is safe, feasible and may improve walking capacity after autoSCT. Findings support a future fully-scaled trial of prehabilitation for autoSCT.

trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12620000496910. Registered April 20, 2020.

Indexed as

Exercise TherapyStem Cell TransplantationAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedNutritional StatusPatient Education as TopicPilot ProjectsPreoperative ExerciseQuality of LifeSingle-Blind MethodTransplantation, AutologousBone marrow transplantCancerExerciseNutritionPrehabilitationSupportive care

Identifiers

PMID39920425
PMCPMC11805779

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.