Evidence map›Paper›PMID 39920420›Full record

ReviewInternational ophthalmology2025

Recurrence of herpetic keratouveitis following cataract surgery.

Laura E Drew-Bear, Raul E Ruiz-Lozano, Kevin Wang, Alejandro Rodriguez-Garcia, Ashley Behrens, Everardo Hernandez-Quintela

Abstract readReview
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In one paragraph

Review in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura E Drew-BearWilmer Eye Institute, Johns Hopkins University, 600 N Wolfe Street, Maumenee Building, Baltimore, MD, 21231, USA.ORCID http://orcid.org/0000-0002-9067-9154
Raul E Ruiz-LozanoTecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.ORCID http://orcid.org/0000-0001-7022-2395
Kevin WangWilmer Eye Institute, Johns Hopkins University, 600 N Wolfe Street, Maumenee Building, Baltimore, MD, 21231, USA.
Alejandro Rodriguez-GarciaTecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.ORCID http://orcid.org/0000-0002-1419-2109
Ashley BehrensWilmer Eye Institute, Johns Hopkins University, 600 N Wolfe Street, Maumenee Building, Baltimore, MD, 21231, USA.
Everardo Hernandez-QuintelaWilmer Eye Institute, Johns Hopkins University, 600 N Wolfe Street, Maumenee Building, Baltimore, MD, 21231, USA. eherna35@jhmi.edu.ORCID http://orcid.org/0000-0002-5734-4168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHerpetic eye disease (HED) is a leading cause of infectious vision loss worldwide. Cataract surgery is known to be implicated in triggering the recurrence of herpes keratouveitis. This study evaluates the current evidence on the association between HED and cataract surgery, focusing on the risk factors and potential pathogenic mechanisms and preventive strategies involved with reactivation or new-onset herpes-related keratitis, uveitis, or keratouveitis.

methodsA comprehensive search of databases (Cinahl, Embase, Scopus, ProQuest, Web of Science, and PubMed) was conducted to identify articles describing the association between new onset or reactivation of HED after cataract surgery up to March 2024. A total of 24 studies were included.

resultsThe heterogeneity of the studies precluded systematic analysis. However, the findings suggest that the herpetic recurrence rate, mainly in the form of keratitis, after cataract surgery is high (approximately 40%), mostly occurring ≤ 2 years after surgery, and can be influenced by factors such as topical corticosteroids, the quiescent time before surgery, and history of prior recurrences, and the patient's comorbidities, including diabetes and atopy. The current evidence for prescribing perioperative HED prophylaxis is of inadequate quality.

conclusionsAvailable evidence suggests that herpetic recurrences tend to occur in the first two years after cataract surgery. A longer quiescent time before surgery might reduce the risk of recurrence. Prospective studies analyzing the effects of perioperative prophylaxis are needed.

Indexed as

Cataract ExtractionEye Infections, ViralKeratitis, HerpeticPostoperative ComplicationsUveitisHumansRecurrenceRisk FactorsCataract surgeryHerpes zoster ophthalmicusHerpetic eye diseaseHerpetic keratitisHerpetic keratouveitisReactivation

Identifiers

PMID39920420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.