Evidence map›Paper›PMID 39920412›Full record

ReviewMolecular and cellular biochemistry2025

The role of sirtuins in the regulation of reactive oxygen species in myocardial ischemia/reperfusion injury.

Zheng Wang, Xiaopeng Zhao, Mingjing Lu, Naiyu Wang, Shu Xu, Dongyu Min, Lijie Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zheng Wang *School of Medicine, Qilu Institute of Technology, Jinan, 250200, China.
Xiaopeng Zhao *College of Exercise and Health, Shenyang Sport University, Shenyang, 110102, China.
Mingjing LuSchool of Medicine, Qilu Institute of Technology, Jinan, 250200, China.
Naiyu WangSchool of Medicine, Qilu Institute of Technology, Jinan, 250200, China.
Shu XuThe Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
Dongyu MinExperimental Center of Traditional Chinese Medicine, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China. mindongyu@163.com.
Lijie WangDepartment of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, 110033, China. wanglj@cmu.edu.cn.

Funding

Liaoning University of Traditional Chinese Medicine Provincial Key Laboratory Post-Subsidy Program 2100220171
6 · The paper itself

Abstract

Myocardial ischemia/reperfusion (I/R) injury has high morbidity and mortality rates, posing a significant burden on society. There is an urgent need to understand its pathogenesis and develop effective treatments. Reactive oxygen species (ROS) are crucial for the development of myocardial I/R injury, and inhibiting ROS overproduction is one of the most critical ways to delay myocardial I/R injury. Sirtuins are a group of nicotinic adenine dinucleotide ( +)-dependent histone deacetylases whose members can regulate ROS by modulating various biological processes. Numerous studies have shown that Sirtuins play an essential role in the progression of myocardial I/R injury by regulating ROS. This study focuses on the relationship between myocardial I/R injury and ROS, Sirtuins and ROS, discusses the role of Sirtuins in regulating ROS in myocardial I/R, and summarizes the therapeutic modalities aimed at targeting Sirtuins to modulate ROS in myocardial I/R injury, thereby guiding future research endeavors.

Indexed as

Myocardial Reperfusion InjuryReactive Oxygen SpeciesSirtuinsAnimalsHumansReactive Oxygen SpeciesSirtuinsMolecular mechanismsMyocardial I/R injuryROSSirtuinsTherapeutic modalities

Identifiers

PMID39920412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.