Evidence map›Paper›PMID 39920379›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2025

Unveiling the metabolomic profile of growth hormone deficiency children using NMR spectroscopy.

Eftychia A Aggelaki, Aristeidis Giannakopoulos, Panagiota D Georgiopoulou, Styliani A Chasapi, Alexandra Efthymiadou, Dimitra Kritikou, Dionisios Chrysis, Georgios A Spyroulias

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Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eftychia A AggelakiDepartment of Pharmacy, School of Health Sciences, University of Patras, 26504, Rio, Greece.
Aristeidis GiannakopoulosDivision of Endocrinology Department of Pediatrics, Medical School, University of Patras, 26504, Rio, Greece.
Panagiota D GeorgiopoulouDepartment of Pharmacy, School of Health Sciences, University of Patras, 26504, Rio, Greece.
Styliani A ChasapiDepartment of Pharmacy, School of Health Sciences, University of Patras, 26504, Rio, Greece.
Alexandra EfthymiadouDivision of Endocrinology Department of Pediatrics, Medical School, University of Patras, 26504, Rio, Greece.
Dimitra KritikouDivision of Endocrinology Department of Pediatrics, Medical School, University of Patras, 26504, Rio, Greece.
Dionisios ChrysisDivision of Endocrinology Department of Pediatrics, Medical School, University of Patras, 26504, Rio, Greece. dchrysis@upatras.gr.
Georgios A SpyrouliasDepartment of Pharmacy, School of Health Sciences, University of Patras, 26504, Rio, Greece. G.A.Spyroulias@upatras.gr.

Funding

ESPERANCE 101087215EU FP7 REGPOT CT-2011-285950"SEE-DRUG" 285950INSPIRED MIS 5002550OMIC-ENGINE 5002636
6 · The paper itself

Abstract

introductionThe diagnosis of Growth Hormone Deficiency (GHD) during childhood has been the subject of much controversy over the last few years. Aiming to accurate medical treatment, there is a need for biomarker discovery.

objectiveTo characterize the metabolic profile of GHD children, examine the effect of GH administration on the metabolic signature, and investigate the correlations between metabolites and IGF-1.

methodsNuclear Magnetic Resonance (NMR)-based untargeted and targeted metabolomic approach applied to study the metabolic profiles of children with GHD. Plasma, serum, and urine samples were collected from twenty-two children diagnosed with GHD and forty-eight age matched controls from the Pediatric Endocrinology Unit of the University Hospital of Patras. Experimental data were examined by both multivariate and univariate statistical analysis.

resultsThe results of this pilot study revealed a different metabolic fingerprint of children with GHD in comparison to age-matched healthy individuals. However, the detected alterations in the metabolite patterns before and after GH treatment were subtle and of minor discriminative statistical power.

conclusionsThis study provides evidence that metabolome plays a pivotal role in GHD, but large-scale multicenter studies are warranted to validate the results.

Indexed as

Human Growth HormoneMetabolomeMetabolomicsAdolescentBiomarkersCase-Control StudiesChildChild, PreschoolFemaleHumansInsulin-Like Growth Factor IMagnetic Resonance SpectroscopyMalePilot ProjectsBiomarkersHuman Growth HormoneInsulin-Like Growth Factor IGrowth hormone deficiencyIGF-1MetabolomicsNMR spectroscopy

Identifiers

PMID39920379
PMCPMC11805833

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