Evidence map›Paper›PMID 39920267›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Effect of probenecid on the whole-body disposition of 6-bromo-7-[

Matthias Jackwerth, Severin Mairinger, Ivo Rausch, Maria Weber, Anselm Jorda, Lukas Nics, Werner Langsteger, Markus Zeitlinger, Marcus Hacker, Oliver Langer

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthias JackwerthDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Severin MairingerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Ivo RauschQIMP Team, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Maria WeberDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Anselm JordaDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Lukas NicsDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Werner LangstegerDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Markus ZeitlingerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Marcus HackerDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. oliver.langer@meduniwien.ac.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMultidrug resistance-associated proteins (MRPs) have a widespread tissue distribution. They play an important role in drug disposition and drug-drug interactions (DDIs) and have been associated with various diseases. PET with 6-bromo-7-[

methodsSeven healthy volunteers (3 women, 4 men) underwent two dynamic whole-body PET scans on a long axial field-of-view (LAFOV) PET/CT system after intravenous injection of [

resultsRadioactivity was primarily excreted into the urinary bladder and urinary clearance was significantly decreased after probenecid administration (- 50 ± 16%). Following probenecid administration, k

conclusionOur study highlights the great potential of LAFOV PET/CT to assess drug disposition and transporter-mediated DDIs in humans at a whole-body, multi-tissue level. Due to the slow elimination of [

trial registrationEudraCT 2021-006348-29. Registered 15 December 2021.

Indexed as

Positron Emission Tomography Computed TomographyProbenecidPurinesWhole Body ImagingAdultCarbon RadioisotopesFemaleHumansMaleMiddle AgedTissue DistributionCarbon-11Carbon RadioisotopesProbenecidPurinesDrug dispositionLong axial field-of-view PET/CTMembrane transportersProbenecidTransporter-mediated drug-drug interaction

Identifiers

PMID39920267
PMCPMC12119383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.