Evidence map›Paper›PMID 39920266›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Improving accuracy of SUV estimates in paediatric oncology: Recommending against the use of body weight corrected SUV in [

Isabelle S A de Vries, Silke Lodema, Arthur J A T Braat, Johannes H M Merks, Rob van Rooij, Bart de Keizer

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. SUV normalisation and reference tissue selection for [European journal of nuclear medicine and molecular imaging · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabelle S A de Vries *Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0001-8289-4164
Silke Lodema *Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Arthur J A T BraatPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0002-8824-8697
Johannes H M MerksPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0001-7659-1028
Rob van RooijDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-8546-8283
Bart de KeizerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. b.dekeizer@umcutrecht.nl.ORCID 0000-0002-6270-9483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew studies have assessed body weight dependency of Standardised Uptake Value (SUV) formulations in paediatric patients. This study aims to compare different SUV formulations measured in reference tissues in paediatric patients and determine which correction method shows the least dependency on body weight.

methodsA single-centre, retrospective analysis of [18F]FDG PET/CT scans was performed. SUV measurements were taken from liver and blood pool using EARL1 reconstructions. SUV measurements were corrected for body weight (SUVBW), lean body mass (LBM) according to James (SUVLBMJames) and Janmahasatian (SUVLBMJanma), and body surface area (BSA) according to DuBois (SUVBSADuBois) and Haycock (SUVBSAHaycock). The coefficient of determination (r

resultsIn total, 461 scans were analysed, including 185 (40%) from female patients. The median age of patients was 12 years (IQR 8-15.5 years). SUVBW exhibited the strongest correlation with body weight, with r

conclusionIn paediatric [18F]FDG PET/CT scans, SUVBW should be avoided due to elevating values in heavier patients. SUVBSA presents the least dependency on body weight and provides the most consistent assessments of metabolic activity.

Indexed as

Body WeightFluorodeoxyglucose F18NeoplasmsPositron Emission Tomography Computed TomographyAdolescentChildFemaleHumansMaleRadiopharmaceuticalsRetrospective StudiesFluorodeoxyglucose F18Radiopharmaceuticals[18F]FDG PET/CTBody weightPaediatric patientsStandardized uptake value

Identifiers

PMID39920266
PMCPMC12119731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.