ArticleScientific reports2025
Comparison of saliva and blood derived cell free RNAs for detecting oral squamous cell carcinoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Liquid Biopsy in the Diagnosis of Oral Squamous Cell Carcinoma: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- EIF2AK2 activates autophagy via JAK2/STAT3 pathway to promote oral squamous cell carcinoma malignancy.Odontology · 2026Article
- Current Trends in Diagnosis and Early Monitoring of Oral Cavity Cancer: Techniques and Biomarkers.Cancers · 2026Review
- Circulating lncRNA as Biomarkers and Therapeutics in Oral Cancer: Silent Scripts with Loud Impact.Molecular biology reports · 2026Review
- Emerging Diagnostic Strategies for Oral Cancer and Oral Potentially Malignant Disorders: A PRISMA-Guided Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- Emerging Salivary Exosome Nanodiagnostics for Early Oral Squamous Cell Carcinoma: Platforms, Biomarkers, and Future Perspectives.International journal of nanomedicine · 2026Review
- Early Molecular Diagnosis and Comprehensive Treatment of Oral Cancer.Current issues in molecular biology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancer types around the world. Although OSCC can be diagnosed or monitored through tissue biopsy, this invasive procedure could cause considerable pain and discomfort to patients. As a preferable alternative, liquid biopsy offers less invasive diagnostics. In our study to enhance OSCC detection, we analyzed cell-free RNA (cfRNA) transcriptomes (mRNA, lncRNA) from blood (plasma) and saliva samples of individuals in three groups: OSCC group, oral benign tumor group, and a normal control group. Our transcriptomic profiling revealed that in the saliva group, CLEC2B was notably upregulated in the OSCC group compared to others, while DAZL, F9, and AC008735.2 were markedly downregulated. However, no OSCC-specific RNAs were identified in the blood (plasma) samples. Furthermore, OSCC group showed a higher neutrophil infiltration and lower B cells, CD4 + T cells (non-regulatory) and regulatory T cell (Tregs) infiltration in oral saliva environment when compared to the control groups. This study suggests that saliva might be a better liquid biopsy medium over blood (plasma) for cfRNA on detecting OSCC. CLEC2B, DAZL, F9, and AC008735.2 in saliva may serve as potential diagnostic liquid biomarkers for OSCC, warranting further investigation.
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Registered trials
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