Evidence map›Paper›PMID 39920223›Full record

ArticleCommunications biology2025

Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB.

So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

So Who Kang *Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Suwon, Gyeonggi-do, Republic of Korea.ORCID http://orcid.org/0000-0001-6611-1991
Jung-Eun Park *Department of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Soonhyuck OkDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Minhui UmDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Hyeonjeong SonDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Seunghee ByunDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-1178-7163
Nayoung ParkDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Su Jin LeeDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Thị Xuân Thùy TrầnDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Gyeongmin KimDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Jeonghun YeomConvergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Songpa-gu, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-9577-1243
Kyunggon KimConvergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Songpa-gu, Seoul, Republic of Korea.
Eun Young KimDepartment of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Suwon, Gyeonggi-do, Republic of Korea. ekim@ajou.ac.kr.ORCID http://orcid.org/0000-0001-6466-8622
Min-Ji KangDepartment of Pharmacology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. mjkang@amc.seoul.kr.ORCID http://orcid.org/0000-0003-1616-1223

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). Here, we investigate the role of ubiquitin-specific peptidase 14 (USP14) in modulating PER stability and circadian rhythms in Drosophila. We find that overexpression of USP14 in clock cells reduces PER protein levels without altering its mRNA levels whereas USP14 knockdown increases PER protein levels, suggesting that USP14 regulates PER post-translationally. Interestingly, despite these alterations in PER levels, neither USP14 overexpression nor knockdown significantly impacts circadian behavioral rhythms, likely because of slight effects on PER levels in small ventral lateral neurons (sLN

Indexed as

Cell Cycle ProteinsDrosophila melanogasterDrosophila ProteinsPeriod Circadian ProteinsUbiquitin-Protein LigasesUbiquitin ThiolesteraseAnimalsCircadian RhythmProtein StabilityUbiquitinationCell Cycle ProteinsDrosophila ProteinsPeriod Circadian ProteinsPER protein, Drosophilaslmb protein, DrosophilaUbiquitin-Protein LigasesUbiquitin Thiolesterase

Identifiers

PMID39920223
PMCPMC11805992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.