Evidence map›Paper›PMID 39920165›Full record

ArticleScientific data2025

A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula.

Nicolás Vidal-Vázquez, Ismael Hernández-Núñez, Pablo Carballo-Pacoret, Sarah Salisbury, Paula R Villamayor, Francisca Hervas-Sotomayor, Xuefei Yuan, Francesco Lamanna, Céline Schneider, Julia Schmidt and 6 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicolás Vidal-Vázquez *Departamento de Bioloxía Funcional, Facultade de Bioloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0001-8899-9522
Ismael Hernández-Núñez *Departamento de Bioloxía Funcional, Facultade de Bioloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Pablo Carballo-PacoretDepartamento de Bioloxía Funcional, Facultade de Bioloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.ORCID http://orcid.org/0009-0005-4095-7637
Sarah SalisburyThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG, UK.
Paula R VillamayorThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG, UK.
Francisca Hervas-SotomayorCenter for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.
Xuefei YuanCenter for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.
Francesco LamannaCenter for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.
Céline SchneiderCenter for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4505-4825
Julia SchmidtCenter for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.
Sylvie MazanCNRS, Sorbonne Université, Biologie Intégrative des Organismes Marins, UMR7232-BIOM, Banyuls-sur-Mer, France.
Henrik KaessmannCenter for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7563-839X
Fátima AdrioDepartamento de Bioloxía Funcional, Facultade de Bioloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-3196-7682
Diego RobledoThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG, UK.ORCID http://orcid.org/0000-0002-9616-5912
Antón Barreiro-IglesiasDepartamento de Bioloxía Funcional, Facultade de Bioloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-7507-080X
Eva CandalDepartamento de Bioloxía Funcional, Facultade de Bioloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. eva.candal@usc.es.ORCID http://orcid.org/0000-0001-6136-7605

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101019268RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/D/30002275, BBS/E/D/30002275, BBS/E/D/10002070, BBS/E/RL/230002AXunta de Galicia ED431C 2021/18
6 · The paper itself

Abstract

The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular diversity in the retina of a variety of species, providing new insights on retinal evolution and development. However, similar data in cartilaginous fishes, the sister group to all other extant jawed vertebrates, are still lacking. Here, we present a single-nucleus RNA sequencing atlas of the postnatal retina of the catshark Scyliorhinus canicula, consisting of the expression profiles for 17,438 individual cells from three female, juvenile catshark specimens. Unsupervised clustering revealed 22 distinct cell types comprising all major retinal cell classes, as well as retinal progenitor cells (whose presence reflects the persistence of proliferative activity in postnatal stages in sharks) and oligodendrocytes. Thus, our dataset serves as a foundation for further studies on the development and function of the catshark retina. Moreover, integration of our atlas with data from other species will allow for a better understanding of vertebrate retinal evolution.

Indexed as

RetinaSharksAnimalsDatasets as TopicFemaleSequence Analysis, RNASingle-Cell Analysis

Identifiers

PMID39920165
PMCPMC11806052

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.