Evidence map›Paper›PMID 39920128›Full record

ArticleNPJ biofilms and microbiomes2025

Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota.

Polina V Popova, Artem O Isakov, Anastasiia N Rusanova, Stanislav I Sitkin, Anna D Anopova, Elena A Vasukova, Alexandra S Tkachuk, Irina S Nemikina, Elizaveta A Stepanova, Angelina I Eriskovskaya and 13 more

Abstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Polina V PopovaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia. pvpopova5@gmail.com.
Artem O IsakovWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Anastasiia N RusanovaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Stanislav I SitkinInstitute of Perinatology and Pediatrics, Almazov National Medical Research Center, Saint Petersburg, Russia.
Anna D AnopovaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Elena A VasukovaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Alexandra S TkachukInstitute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Irina S NemikinaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Elizaveta A StepanovaInstitute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Angelina I EriskovskayaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Ekaterina A StepanovaInstitute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Evgenii A PustozerovInstitute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Maria A KokinaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Elena Y VasilievaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Lyudmila B VasilyevaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Soha ZgairyAzrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
Elad RubinAzrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
Carmel EvenAzrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
Sondra TurjemanAzrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
Tatiana M PervuninaInstitute of Perinatology and Pediatrics, Almazov National Medical Research Center, Saint Petersburg, Russia.
Elena N GrinevaWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Omry KorenAzrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
Evgeny V ShlyakhtoWorld-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2022-301
6 · The paper itself

Abstract

We developed a prediction model for postprandial glycemic response (PPGR) in pregnant women, including those with diet-treated gestational diabetes mellitus (GDM) and healthy women, and explored the role of gut microbiota in improving prediction accuracy. The study involved 105 pregnant women (77 with GDM, 28 healthy), who underwent continuous glucose monitoring (CGM) for 7 days, provided food diaries, and gave stool samples for microbiome analysis. Machine learning models were created using CGM data, meal content, lifestyle factors, biochemical parameters, and microbiota data (16S rRNA gene sequence analysis). Adding microbiome data increased the explained variance in peak glycemic levels (GLUmax) from 34 to 42% and in incremental area under the glycemic curve (iAUC120) from 50 to 52%. The final model showed better correlation with measured PPGRs than one based only on carbohydrate count (r = 0.72 vs. r = 0.51 for iAUC120). Although microbiome features were important, their contribution to model performance was modest.

Indexed as

Blood GlucoseDiabetes, GestationalGastrointestinal MicrobiomeAdultBacteriaFecesFemaleHumansMachine LearningPostprandial PeriodPregnancyRNA, Ribosomal, 16SBlood GlucoseRNA, Ribosomal, 16S

Identifiers

PMID39920128
PMCPMC11806021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.