ArticleNature communications2025
Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Construction of multifunctionalized (oxo)indoles via O-Selective interception of the zwitterionic intermediate with N=O.Molecular diversity · 2026Article
- Asymmetric C2-functionalization of indoles via visible-light-promoted three-component reaction.Molecular diversity · 2026Article
- Palladium-catalyzed borylative coupling of hypervalent iodine diazo reagents with boranes for the synthesis of organoboron carboxylate.Molecular diversity · 2026Article
- Tunable Skeletal Editing of Benzothiazole and Benzisothiazole Via Carbene Transfer Reactions.JACS Au · 2025Article
- Catalytic Oxidative Ligand Transfer of Rh-Carbynoids and Alkyl Iodides.Journal of the American Chemical Society · 2025Article
- Multicatalysis-Enabled Multicomponent Reactions Generate a PTP1B Inhibitor.ACS central science · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Multi-component multi-functionalization reactions involving active intermediates are powerful tools for rapidly generating a wide array of compounds. Metal carbynoids, with their distinct reactivity, hold great promise for developing synthetic methodologies. However, their application in catalytic transfer reactions has been hindered by the limited availability of suitable precursors. In this study, we investigate the catalytic potential of α-halo Rh-carbenes, leveraging the concept of metal carbynoids in multi-functionalization reactions. Through a chiral phosphoric acid-catalyzed asymmetric trifunctionalization, we have developed a method for synthesizing a variety of chiral α-cyclic ketal β-amino esters with high yields and excellent enantioselectivity. Our extensive experimental and computational studies reveal that α-halo Rh-carbenes exhibit carbynoid properties, which facilitate the transformation into functionalized Fischer-type Rh-carbenes through the decomposition of the C-halo bond.
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Registered trials
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