Evidence map›Paper›PMID 39920102›Full record

ArticleNature communications2025

WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis.

Weiliang Jiang, Bingjie Guan, Hongcheng Sun, Yushuai Mi, Sanjun Cai, Rong Wan, Xinxiang Li, Peng Lian, Dawei Li, Senlin Zhao

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
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  10. Cadherin 17 and digestive cancers: from diagnostic to therapeutic opportunities.Journal of experimental & clinical cancer research : CR · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Overcoming resistance to anti-PD-1/PD-L1 therapy in cancer.Cancer drug resistance (Alhambra, Calif.) · 2026
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weiliang Jiang *Cancer Institute, Fudan University Shanghai Cancer Center, No. 270 Dong'an Road, Shanghai, China.
Bingjie Guan *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Shanghai, China.ORCID http://orcid.org/0000-0002-3709-291X
Hongcheng Sun *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Shanghai, China.
Yushuai Mi *Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Road, Jinan, Shandong, China.
Sanjun CaiCancer Institute, Fudan University Shanghai Cancer Center, No. 270 Dong'an Road, Shanghai, China.
Rong WanDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, China.
Xinxiang LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong'an Road, Shanghai, China.ORCID http://orcid.org/0000-0002-2354-4735
Peng LianDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong'an Road, Shanghai, China.
Dawei LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong'an Road, Shanghai, China. li_dawei@fudan.edu.cn.ORCID http://orcid.org/0000-0002-5642-4000
Senlin ZhaoDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong'an Road, Shanghai, China. sunshinezsl1989@163.com.ORCID http://orcid.org/0000-0001-7079-0771

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82370656National Natural Science Foundation of China (National Science Foundation of China) 82372643Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 23ZR1450900
6 · The paper itself

Abstract

Liver metastasis (LM) poses a significant challenge in cancer treatment, with limited available therapeutic options and poor prognosis. Understanding the dynamics of tumor microenvironment (TME) and immune interactions is crucial for developing effective treatments. We find that WNT11 promoted CD8

Indexed as

Drug Resistance, NeoplasmImmune Checkpoint InhibitorsImmune EvasionLiver NeoplasmsProgrammed Cell Death 1 ReceptorWnt ProteinsAnimalsbeta CateninCalcium-Calmodulin-Dependent Protein Kinase Type 2CD8-Positive T-LymphocytesCell Line, TumorColorectal NeoplasmsFemaleHumansMacrophagesMalebeta CateninCalcium-Calmodulin-Dependent Protein Kinase Type 2Immune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorWnt Proteins

Identifiers

PMID39920102
PMCPMC11806061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.