Evidence map›Paper›PMID 39920100›Full record

ArticleNature communications2025

Structural basis of inhibition of human Na

Bryan Neumann, Stephen McCarthy, Shane Gonen

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. The Excelsatoxin A-Receptor TMEM233 Modulates Nav1.8.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Review
  4. Article
  5. Targeting NaInternational journal of molecular sciences · 2026
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Bryan NeumannDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-9596-1300
Stephen McCarthyDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Shane GonenDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA. gonens@uci.edu.ORCID http://orcid.org/0000-0002-4829-3151

Funding

Breaking barriers in CryoEM through computational protein designR35GM142797 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GONEN, SHANE · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM142797United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA1-21-1-0004U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM142797
6 · The paper itself

Abstract

Voltage-gated sodium channels (Na

Indexed as

NAV1.8 Voltage-Gated Sodium ChannelPeptidesSpider VenomsVoltage-Gated Sodium Channel BlockersCryoelectron MicroscopyHumansIon Channel GatingModels, MolecularNAV1.8 Voltage-Gated Sodium ChannelPeptidesSpider VenomsVoltage-Gated Sodium Channel Blockers

Identifiers

PMID39920100
PMCPMC11805909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.