Evidence map›Paper›PMID 39920095›Full record

ArticleChemistry & biodiversity2025

Antifouling Activity of Xylemin, Its Structural Analogs, and Related Polyamines.

Hiroyoshi Takamura, Takefumi Yorisue, Kenta Tanaka, Isao Kadota

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hiroyoshi TakamuraDepartment of Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0002-8330-969X
Takefumi YorisueInstitute of Natural and Environmental Sciences, University of Hyogo, Sanda, Japan.ORCID https://orcid.org/0000-0003-0320-0350
Kenta TanakaResearch Institute for Interdisciplinary Science, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0001-8253-3561
Isao KadotaDepartment of Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.

Funding

Japan Society for the Promotion of Science JP20K15576Japan Society for the Promotion of Science JP21H01938Japan Society for the Promotion of Science JP23K21115Japan Society for the Promotion of Science KAKENHIJKA Foundation 2024M-570
6 · The paper itself

Abstract

Biofouling, which is the accumulation of organisms on undersea structures, poses significant global, social, and economic issues. Although organotin compounds were effective antifoulants since the 1960s, they were banned in 2008 due to their toxicity to marine life. Although tin-free alternatives have been developed, they also raise environmental concerns. This underscores the need for effective, nontoxic antifouling agents. We previously synthesized N-(4-aminobutyl)propylamine (xylemin) and its structural analogs. In this study, we assayed the antifouling activity and toxicity of xylemin, its structural analogs, and related polyamines toward cypris larvae of the barnacle Amphibalanus amphitrite. Xylemin and its Boc-protected analog exhibited antifouling activities with 50% effective concentrations (EC

Indexed as

BiofoulingPolyaminesPropylaminesThoracicaAnimalsDose-Response Relationship, DrugLarvaMolecular StructureStructure-Activity RelationshipPolyaminesPropylaminesAminesAntifouling activityBarnacleStructure–activity relationshipsXylemin

Identifiers

PMID39920095
PMCPMC12004904

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.