Evidence map›Paper›PMID 39919878›Full record

ReviewEndocrinology and metabolism clinics of North America2025

Intermittent Fasting: Implications for Obesity-Related Colorectal Tumorigenesis.

Beatriz Peñalver Bernabé, Manoela Lima Oliveira, Patricia G Wolf, Andrew McLeod, Kelsey Gabel, Kate Cares, Nadia Robinson, Brittany DiPiazza, Krista Varady, Lisa Tussing-Humphreys

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrinology and metabolism clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Intermittent fasting enhances cancer therapyWorld journal of clinical oncology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Beatriz Peñalver BernabéDepartment of Biomedical Engineering, University of Illinois Chicago, 851 South Morgan Street, Chicago, IL, USA; Center for Bioinformatics and Quantitative Biology, University of Illinois Chicago, Chicago, IL, USA.
Manoela Lima OliveiraDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA; University of Illinois Cancer Center, Chicago, IL, USA.
Patricia G WolfDepartment of Nutrition Science, Purdue University, 700 Mitch Daniels Boulevard, West Lafayette, IN, USA; Purdue Institute for Cancer Research, West Lafayette, IN, USA.
Andrew McLeodDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA; University of Illinois Cancer Center, Chicago, IL, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA; Department of Nutrition Science, Purdue University, 700 Mitch Daniels Boulevard, West Lafayette, IN, USA.
Kate CaresDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA.
Nadia RobinsonCollege of Nursing, University of Illinois Chicago, 845 South Damen Avenue, MC 802, Chicago, IL, USA.
Brittany DiPiazzaDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA.
Krista VaradyDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA.
Lisa Tussing-HumphreysDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA; University of Illinois Cancer Center, Chicago, IL, USA. Electronic address: tussing@uic.edu.

Funding

Mediating Role of Gut Microbiota in the Regulation of Colorectal Cancer Risk in the Context of Time-restricted Eating and Calorie RestrictionR01CA257807 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Lisa Tussing-Humphreys, Krista Amy Varady · 2021 to 2026
$5.4M
Cancer Health Equity Career Development ProgramT32CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Marian L. Fitzgibbon · 2018 to 2026
$3.0M
NCI NIH HHS R01 CA257807NCI NIH HHS T32 CA057699
6 · The paper itself

Abstract

Obesity is associated with metabolic and immune perturbations (ie, insulin resistance, increased inflammation, and oxidative stress), circadian rhythm dysregulation, and gut microbial changes that can promote colorectal tumorigenesis. Colorectal cancer (CRC) is the third most incident cancer in the United States. This narrative review examines the effects of intermittend fasting on factors influencing colon tumorigenesis, such as body weight, metabolic and immune markers, circadian rythm, and the gut microbiota in humans. Findings suggest that intermittent fasting regimens can lead to weight loss and shifts in metabolic markers, which could be preventive for CRC but effects on the gut microbiota composition and functions still remains elusive.

Indexed as

CarcinogenesisColorectal NeoplasmsFastingObesityAnimalsGastrointestinal MicrobiomeHumansIntermittent FastingCircadian rhythmColorectal cancerGut microbiomeIntermittent fastingObesity

Identifiers

PMID39919878
PMCPMC12240480

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.