PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities.
Bunu Lama, Hyewon Park, Anita Saraf, Victoria Hassebroek, Daniel Keifenheim, Tomoko Saito-Fujita, Noriko Saitoh, Vasilisa Aksenova, Alexei Arnaoutov, Mary Dasso and 2 more
Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
12 authors.
Bunu LamaDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.
Hyewon ParkDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.
Anita SarafMass Spectrometry and Analytical Proteomics Laboratory, University of Kansas, Lawrence, KS, USA.
Victoria HassebroekDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.
Daniel KeifenheimDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Tomoko Saito-FujitaDivision of Cancer Biology, The Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.
Noriko SaitohDivision of Cancer Biology, The Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID 0000-0002-2601-2806
Vasilisa AksenovaDivision of Molecular and Cellular Biology, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Alexei ArnaoutovDivision of Molecular and Cellular Biology, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Mary DassoDivision of Molecular and Cellular Biology, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5410-1371
Duncan J ClarkeDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7795-3294
Yoshiaki AzumaDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS, USA azumay@ku.edu.ORCID 0000-0002-9634-6676
Funding
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
SUMO family Ubiquitin-like Modifiers In Higher EukaryotesZIAHD001902 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DASSO, MARY C. · 2009 to 2021
$6.3M
Control of Chromosome Segregation by DNA Topoisomerase IIR01GM130858 · NIGMS · UNIVERSITY OF MINNESOTA · PI DUNCAN J. CLARKE · 2019 to 2026
$2.2M
Regulation of kinetochore function by Topoisomerase IIR01GM112793 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI AZUMA, YOSHIAKI, CLARKE, DUNCAN J. · 2015 to 2018
$1.2M
A high-throughput screen for inhibitors of Plk1-interacting checkpoint helicase (PICH)R21CA259718 · NCI · UNIVERSITY OF MINNESOTA · PI AZUMA, YOSHIAKI, CLARKE, DUNCAN J. · 2022 to 2023
Either inhibiting or stabilizing SUMOylation in mitosis causes defects in chromosome segregation, suggesting that dynamic mitotic SUMOylation of proteins is critical to maintain integrity of the genome. Polo-like kinase 1-interacting checkpoint helicase (PICH), a mitotic chromatin remodeling enzyme, interacts with SUMOylated chromosomal proteins via three
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities. · full record | OpenQuestion