ReviewExperimental physiology2026
The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.
Review in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study.The Journal of physiology · 2026Trial
- Limited musculoskeletal benefits of artificial gravity combined with cycling during bed rest: Results from the BRACE study.Experimental physiology · 2026Trial
- The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.Experimental physiology · 2026Review
- Decoding the space integrome: Personalized countermeasures for a mission to Mars.Experimental physiology · 2026Article
- The physiology of survival: Space.Experimental physiology · 2026Article
- Entering a new era for exercise countermeasures in human spaceflight.Experimental physiology · 2026Article
- Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest: BRAVE study.Experimental physiology · 2026Article
- Kinematic analysis of the European Enhanced Exploration Exercise Device in unpowered mode.NPJ microgravity · 2026Article
- Cardiovascular response to altered gravity in healthy adults: Insight from graded tilt testing.Physiological reports · 2026Article
- Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.NPJ microgravity · 2025Review
- 3D bioprinting bone/cartilage organoids: construction, applications, and challenges.Journal of orthopaedic translation · 2025Review
- Recovery of bone microarchitecture and density four years after spaceflight: two case studies.NPJ microgravity · 2025Article
- IoT-based bed and ventilator management system during the COVID-19 pandemic.Scientific reports · 2025Article
- Science of omics: a molecular space odyssey.Experimental physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The current understanding of crew health maintenance is founded upon decades of physiological research conducted in terrestrial spaceflight analogues and in low Earth orbit, particularly on the International Space Station. However, as we progress towards the Lunar Gateway and interplanetary missions, it is imperative that the tools employed to maintain crew health are redefined, including the utilisation of exercise countermeasures. The successful implementation of exercise countermeasures for deep space missions must address a number of challenges, including those posed by new environments with elevated levels of cosmic radiation and solar particle events, extended mission durations and constrained space availability. In this Topical Review, the authors address points that are important (and sometimes critical), but often ignored, in order to define future exercise countermeasures for long-duration space missions. Multi-organ countermeasures, countermeasure enjoyment, time-dependent load variability, the relationship between nutrition and the success of exercise countermeasures, and the individual variability in response to a given countermeasure are presented and discussed. The aim of this article is to raise awareness of important aspects that can profoundly influence the efficacy of exercise countermeasures, thereby affecting the health of the crew and the success of the mission during prolonged spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.