ReviewEndocrinology2025
The Hypothalamic Arcuate Nucleus Dopaminergic Neurons: More Than Just Prolactin Secretion.
Review in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Pick a color to control TRP channels.Nature chemical biology · 2026Article
- Article
- Review of the effect of atrazine on the HPG axes and steroidogenic pathways in males: relevance for testicular and prostate cancer.Frontiers in toxicology · 2025Review
- Proteomic insights into the biology of dopaminergic neurons.Frontiers in molecular neuroscience · 2025Review
- Are There Connections between the Neuroendocrine and Dopamine Systems in Bipolar Disorder?Neuroendocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The hypothalamic arcuate nucleus dopaminergic (A12) neurons are well known for their central role in regulating prolactin secretion through a sophisticated negative feedback loop. In this canonical pathway, prolactin stimulates A12 neurons to release dopamine, which suppresses further prolactin release from lactotrophs in the anterior pituitary. However, a collective of recent and past evidence strongly implies that the A12 neurons are far more dynamic and multifaceted than previously appreciated. This minireview discusses the developmental trajectory of A12 neurons, from prenatal origins to postnatal maturation, highlighting their diversity and heterogeneity. Beyond their well-characterized role in prolactin regulation, the A12 neurons contribute to a broader array of hypothalamic functions, including autoregulation, metabolism, and growth. By shedding light on these underexplored roles, this review outlines the expansive significance of A12 neurons as more than mere gatekeepers of prolactin secretion, positioning them as versatile players in endocrine and metabolic homeostasis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.