Evidence map›Paper›PMID 39918923›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

Short-Term Acid Sphingomyelinase Deficiency Exerts Proinflammatory and Antiapoptotic Effects during LPS-induced Lung Injury in Mice.

Joanna M Poczobutt, Nicholas Egersdorf, Max S Hiltabidle, Koichi Nishino, Matthew J Justice, Tanner Rivera, Betty Dubois, Alexander Borowiec, S Ali Mousavi-Aghdas, Katrina Kopf and 4 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Molecular Maestro in the Lung: The Sphingolipid Rheostat.American journal of respiratory cell and molecular biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Joanna M PoczobuttDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.
Nicholas EgersdorfDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0009-0005-4471-3963
Max S HiltabidleDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0000-0002-5806-1485
Koichi NishinoDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0009-0005-8127-6539
Matthew J JusticeDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0009-0007-4850-8320
Tanner RiveraDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0009-0000-2038-8733
Betty DuboisDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.
Alexander BorowiecDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.
S Ali Mousavi-AghdasDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0000-0001-9408-3596
Katrina KopfDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0009-0007-6887-7545
Fabienne GallyDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0003-0503-7411
Jennifer MatsudaDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0002-9191-9893
Evgeny V BerdyshevDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0000-0002-1376-0098
Irina PetracheDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and.ORCID 0000-0003-1094-2600

Funding

Ceramide-induced Lung Destruction in EmphysemaR01HL077328 · NHLBI · NATIONAL JEWISH HEALTH · PI PETRACHE, IRINA · 2006 to 2024
$8.0M
Role of FABP5 in COPD ExacerbationsR01HL141264 · NHLBI · NATIONAL JEWISH HEALTH · PI Fabienne Gally · 2019 to 2026
$3.7M
NHLBI NIH HHS R01 HL077328NHLBI NIH HHS R01 HL141264NIH HHS R01HL077328U.S. Department of Defense PR210173/PR210173P1Wollowick Chair of Pulmonary Research, National Jewish Health
6 · The paper itself

Abstract

Lysosomal acid sphingomyelinase (ASM; SMPD1) deficiency causes Niemann-Pick disease that, in type B, manifests with interstitial lung disease and susceptibility to infections. Constitutional

Indexed as

Acute Lung InjuryApoptosisInflammationLipopolysaccharidesLung InjurySphingomyelin PhosphodiesteraseAnimalsCeramidesLungMiceMice, Inbred C57BLMice, KnockoutSphingolipidsSphingomyelinsASMase, mouseCeramidesLipopolysaccharidesSphingolipidsSphingomyelin PhosphodiesteraseSphingomyelinsceramideconditional knockoutendotheliumrepairsphingolipids

Identifiers

PMID39918923
PMCPMC12335286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.