Evidence map›Paper›PMID 39918762›Full record

ArticleJournal of assisted reproduction and genetics2025

Analysis of Tanner stage in children conceived after the diagnosis of infertility: the DESCRT study.

Jane Y Liu, Richard Hu, Robert H Lustig, David Huang, Amanda J Adeleye, Paolo Rinaudo, Marcelle I Cedars, Lydia B Zablotska

Abstract read
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In one paragraph

Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jane Y LiuSchool of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA.
Richard HuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94158, USA.
Robert H LustigDepartment of Pediatrics, University of California, San Francisco, CA, 94158, USA.
David HuangDepartment of Obstetrics Gynecology and Reproductive Sciences, University of California, San Francisco, CA, 94158, USA.
Amanda J AdeleyeDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL, 60637, USA.
Paolo RinaudoDepartment of Obstetrics Gynecology and Reproductive Sciences, University of California, San Francisco, CA, 94158, USA.
Marcelle I CedarsDepartment of Obstetrics Gynecology and Reproductive Sciences, University of California, San Francisco, CA, 94158, USA.
Lydia B ZablotskaDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94158, USA. Lydia.zablotska@ucsf.edu.ORCID http://orcid.org/0000-0002-0778-1108

Funding

National Institute of Child Health and Human Development 1R01HD084380-01A1
6 · The paper itself

Abstract

purposeUse of assisted reproductive technology (ART) could lead to abnormal pubertal development in children. We compared pubertal development in children conceived using ART to non-in vitro fertilization fertility treatment (NIFT) and unassisted (UA) conception.

methodsChildren from the Developmental Epidemiological Study of Children through Reproductive Technology (DESCRT) were assessed for pubertal development according to the standardized protocol. Tanner staging (breast, testes, and pubic hair development) was compared between ART, NIFT, and UA-conceived children. Differences were analyzed using Wilcoxon rank-sum test, Pearson's chi-squared test, and Fisher's exact test. Multivariable logistic regression was used to assess association between method of conception and pubertal development.

resultsThe sample included 290 children (164 boys and 126 girls) at median age 6 years (range 4 to 18 years); 229 were conceived using ART compared to a combined reference group of 29 conceived via NIFT and 32 via UA. Statistical analyses adjusted for children's age, height, and weight showed statistically non-significant trends wherein boys conceived via ART tended to be in later Tanner stages for pubarche (OR = 2.33, 95% CI 0.44-12.21) and gonadarche (OR = 4.27, 95% CI 0.44-41.99), and girls tended to be in later stages for pubarche (OR = 4.29, 95% CI 0.40-45.62) and thelarche (OR = 2.23, 95% CI 0.35-14.03) compared to the reference group.

conclusionAs ART becomes more widespread, developmental concerns become increasingly prominent. While results were statistically non-significant, we observed a trend toward differences in pubertal development between ART-conceived children and those conceived without assistance or NIFT.

Indexed as

InfertilityPubertyReproductive Techniques, AssistedSexual MaturationAdolescentChildChild, PreschoolFemaleFertilization in VitroHumansMaleARTICSIIVFPubertyTanner stage

Identifiers

PMID39918762
PMCPMC12055717

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.