Evidence map›Paper›PMID 39918646›Full record

ArticleActa parasitologica2025

Neospora caninum Inhibits Lewis Cancer and B16f10 Melanoma Lung Metastasis Development by Activating the Immune Response in Murine Models.

Weifeng Qian, Yaqi Chen, Chen Li, Xiaojin Li, Chaochao Lv, Yanyan Jia, Suhui Hu, Min Zhang, Tianqi Wang, Wenchao Yan and 1 more

Abstract read
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In one paragraph

Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weifeng QianCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China. qwf2012@yeah.net.
Yaqi ChenCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Chen LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Xiaojin LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Chaochao LvCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Yanyan JiaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Suhui HuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Min ZhangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Tianqi WangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Wenchao YanCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Meng QiCollege of Animal Science, Tarim University, Alar, Xinjiang, 843300, China. qimengdz@163.com.

Funding

National Natural Science Foundation of China 31502053
6 · The paper itself

Abstract

Malignant tumors are prevalent with high mortality rates in humans, dogs, and cats. Some microorganisms have been shown to inhibit cancer progression. The objective of this study is to evaluate the inhibitory effects of Neospora caninum, a livestock parasite, on three different tumor models in C57BL/6 mice, including Lewis subcutaneous tumors, Lewis and B16F10 melanoma lung metastasis. The results showed that a sufficient amount of N. caninum tachyzoites can significantly inhibit the development of subcutaneous tumors and lung metastasis (P < 0.001), and induce more than 50% tumor cell death in Lewis subcutaneous tumors. N. caninum treatment can significantly increases the infiltration of macrophages, NK cells, and CD8

Indexed as

Lung NeoplasmsMelanoma, ExperimentalNeosporaAnimalsCytokinesDisease Models, AnimalFemaleMiceMice, Inbred C57BLCytokinesCytokinesImmune cellsMetastasisNeospora caninumSubcutaneous tumors

Identifiers

PMID39918646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.