Evidence map›Paper›PMID 39918485›Full record

ArticleJournal of materials chemistry. B2025

Citrus pectin-coated inhalable PLGA nanoparticles for treatment of pulmonary fibrosis.

Kalindu Perera, Moez Ghumman, Parand Sorkhdini, Carmelissa Norbrun, Seraphina Negash, Yang Zhou, Jyothi U Menon

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kalindu PereraDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. jmenon@uri.edu.ORCID http://orcid.org/0000-0001-8859-4189
Moez GhummanDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. jmenon@uri.edu.ORCID http://orcid.org/0000-0001-9337-0032
Parand SorkhdiniDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA.
Carmelissa NorbrunDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA.
Seraphina NegashDepartment of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA.
Yang ZhouDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA.
Jyothi U MenonDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. jmenon@uri.edu.ORCID http://orcid.org/0000-0002-0762-3513

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Defining the role of cytomegalovirus in glioblastoma therapiesR01CA263324 · NCI · BROWN UNIVERSITY · PI CHARLES H COOK, Sean Edward Lawler · 2022 to 2026
$3.4M
Targeting CHI3L and its receptors in Hermansky-Pudlak Syndrome-associated lung diseaseR01HL146498 · NHLBI · BROWN UNIVERSITY · PI ZHOU, YANG · 2020 to 2024
$2.2M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
Multifunctional Nanoparticle Platform to Prevent Alcohol-Associated HCC DevelopmentR37CA283937 · NCI · UNIVERSITY OF RHODE ISLAND · PI Jyothi Unnikrishna Menon · 2023 to 2026
$1.5M
Interdisciplinary training in pharmacological sciencesT32GM139793 · NIGMS · BROWN UNIVERSITY · PI Diana M Horrigan, Sean Edward Lawler · 2021 to 2026
$1.3M
Nanoparticle-mediated targeting of hepatic macrophages to mitigate inflammation in alcoholic liver diseaseR21AA029750 · NIAAA · UNIVERSITY OF RHODE ISLAND · PI MENON, JYOTHI UNNIKRISHNA · 2022 to 2023
$413k
NCI NIH HHS R01 CA263324NCI NIH HHS R37 CA283937NHLBI NIH HHS R01 HL146498NHLBI NIH HHS R25 HL088992NHLBI NIH HHS T32 HL134625NIAAA NIH HHS R21 AA029750NIGMS NIH HHS P20 GM103652NIGMS NIH HHS T32 GM139793
6 · The paper itself

Abstract

Pulmonary fibrosis (PF) is a chronic interstitial disorder of the respiratory system that can be debilitating as it progresses and has experienced a slow rise in incidence in past years. Treatment is complicated by the complex aetiology of the disease and the off-target effects of the two FDA-approved therapeutics available on the market: pirfenidone and nintedanib. In this work, we propose a multipurpose nanoparticle system consisting of poly(lactic-

Indexed as

NanoparticlesPectinsPolylactic Acid-Polyglycolic Acid CopolymerPulmonary FibrosisAdministration, InhalationAnimalsBleomycinCell LineCitrusGalectin 3HumansMiceMice, Inbred C57BLParticle SizeBleomycincitrus pectinGalectin 3PectinsPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID39918485
PMCPMC11804936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.