Evidence map›Paper›PMID 39918314›Full record

ArticlemSystems2025

Timing matters in macrophage/CD4+ T cell interactions: an agent-based model comparing

Alexis Hoerter, Alexa Petrucciani, Jordan Bonifacio, Eusondia Arnett, Larry S Schlesinger, Elsje Pienaar

Abstract readComparative Study
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexis HoerterWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-6667-1796
Alexa PetruccianiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Jordan BonifacioTexas Biomedical Research Institute, San Antonio, Texas, USA.
Eusondia ArnettTexas Biomedical Research Institute, San Antonio, Texas, USA.
Larry S SchlesingerTexas Biomedical Research Institute, San Antonio, Texas, USA.
Elsje PienaarWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-5408-8795

Funding

Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection- Diversity SupplementR01AI136831 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Eusondia A. Arnett, Larry S. Schlesinger · 2019 to 2026
$4.6M
NRSA Training CoreTL1TR002531 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI FOTI, DANIEL JUSTIN, HURLEY, THOMAS D. · 2018 to 2022
$2.5M
Effect of HIV infection on M.tuberculosis granuloma formation and evolutionR21AI145539 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI KULKARNI, SMITA, SCHLESINGER, LARRY S. · 2019 to 2020
$536k
HHS | National Institutes of Health (NIH) AI136831, AI145539, 1P30AI168439Indiana Clinical and Translational Sciences Institute (CTSI) TL1TR002531NCATS NIH HHS TL1 TR002531NIAID NIH HHS P30 AI168439NIAID NIH HHS R01 AI136831NIAID NIH HHS R21 AI145539Pharmaceutical Research and Manufacturers of America Foundation (PhRMAF)Texas Biomedical Research Institute (Texas Biomed)
6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Indexed as

CD4-Positive T-LymphocytesHost-Pathogen InteractionsLatent TuberculosisMacrophagesMycobacterium tuberculosisComputer SimulationGranulomaHumansTime FactorsTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaagent based modelcomputational modelgranuloma formationhost-cell interactionshost responsetrained immunitytuberculosis

Identifiers

PMID39918314
PMCPMC11915833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.