Evidence map›Paper›PMID 39918275›Full record

ArticleGut microbes2025

Alterations in mucosa branched

Cláudia S Rodrigues, Joana Gaifem, Márcia S Pereira, Maria Francisca Alves, Mariana Silva, Nuno Padrão, Bruno Cavadas, Catarina Moreira-Barbosa, Inês Alves, Ricardo Marcos-Pinto and 5 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cláudia S RodriguesInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0002-9922-1879
Joana GaifemInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0001-7306-7378
Márcia S PereiraInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0002-8708-8388
Maria Francisca AlvesInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0009-0001-8580-6948
Mariana SilvaInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0002-1988-1093
Nuno PadrãoInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0002-8368-2806
Bruno CavadasInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0003-4104-5398
Catarina Moreira-BarbosaHospital da Luz Learning Health, Luz Saúde, Lisbon, Portugal.ORCID 0000-0003-4484-9922
Inês AlvesInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0002-3914-7101
Ricardo Marcos-PintoSchool of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.ORCID 0000-0001-9695-8261
Joana TorresDivision of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal.ORCID 0000-0003-2895-5821
Aonghus LavelleCentre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Gastroenterology Department, Sorbonne Université, INSERM, Paris, France.ORCID 0000-0002-4461-8596
Jean-Frederic ColombelHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6472-249X
Harry SokolCentre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Gastroenterology Department, Sorbonne Université, INSERM, Paris, France.ORCID 0000-0002-2914-1822
Salomé S PinhoInstitute for Research and Innovation in Health (i3S), Immunology, Cancer & Glycomedicine Group, University of Porto, Porto, Portugal.ORCID 0000-0002-3484-5162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological interface between gut microorganisms and host immunity that remains ill-defined. Glycans are essential players in IBD immunopathogenesis, even years before disease onset. However, how changes in mucosa glycosylation shape microbiome and how this impact gut immune response and inflammation remains to be clarified. Here, we revealed that alterations in the expression of complex branched

Indexed as

DysbiosisInflammatory Bowel DiseasesIntestinal MucosaLymphocytesPolysaccharidesAnimalsDisease Models, AnimalDown-RegulationFemaleGastrointestinal MicrobiomeGlycosylationHumansImmunity, InnateInflammationMaleMicePolysaccharidesILC3intestinal inflammationmicrobiomeN-glycansprophylaxis

Identifiers

PMID39918275
PMCPMC11810091

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.