ArticleJournal of cosmetic dermatology2025
The Response of Patients' Immune System After Facial Mesotherapy.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comment on Published Article "Platelet Rich Plasma Resultant Cutaneous Nodules on Scalp".Indian dermatology online journal · 2026Article
- Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study.Plastic and reconstructive surgery. Global open · 2026Article
- Clinical Efficacy of Tofacitinib in Treating Granulomatous Reaction After Mesotherapy: A Case Series Analysis.Journal of cosmetic dermatology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFacial mesotherapy is a minimally invasive cosmetic procedure involving the injection of active substances into the dermis and subcutaneous tissue. Although generally considered safe, complications such as granulomatous inflammation can arise due to improper techniques or unregulated products. This case report highlights the immune response to facial mesotherapy and its clinical management. MATERIALS AND
methodsA 50-year-old woman presented with erythematous, hard, and painless facial nodules three weeks after undergoing mesotherapy in a non-medical setting. A detailed clinical examination, laboratory tests, histopathological analysis, and immunohistochemical evaluation were performed. Tissue expression of CD3, CD20, and CD68 markers was quantified using morphometric analysis. Statistical analysis was conducted to compare the expression of immune markers.
resultsHistopathological examination revealed granulomatous inflammation dominated by macrophages. Immunohistochemical analysis showed significantly higher macrophage activity (CD68, mean reaction area: 5,982.76 µm
conclusionGranulomatous inflammation is a potential complication of facial mesotherapy, particularly when performed in non-medical settings. Effective management requires timely diagnosis, a combination of systemic and topical treatments, and long-term follow-up. This case underscores the need for standardized mesotherapy protocols and medical oversight to minimize risks.
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