Trial reportCurrent pharmaceutical design2025
Efficacy of Roxadustat in Anemia with Chronic Kidney Disease.
Trial report in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnemia is one of the complications of chronic kidney disease (CKD), and its incidence gradually increases as the disease progresses. A major cause of such anemia is the severe erythropoietin deficiency in CKD. Therefore, improvement in red blood cell production is a choice of treatment. Erythropoiesis- stimulating agents (ESAs) have been used for the therapy of anemia induced in CKD. Roxadustat is a novel drug for improving such anemia. This study aimed to compare the efficacy of roxadustat and ESAs in patients with CKD. MATERIALS AND
methodsA retrospective analysis of CKD patients with anemia who regularly use roxadustat and ESAs in the Nephrology Department of the Second Affiliated Hospital of Shantou University School of Medicine was carried out. Baseline clinical data and clinical indicators during the medication period were collected and analyzed in both groups.
resultsIn this retrospective study, we found that roxadustat was effective in improving anemia. The anemia rate, Hb<11g/dL, before treatment in patients with CKD was 94.55%. The standard rate of patients with CKD anemia was 25.45% after one month of treatment, 54.54% after three months of treatment, and 65.45% after six months of treatment. In the clinical observations of the medication, roxadustat did not differ from ESAs in the treatment of anemia in CKD. However, roxadustat did not improve micro-inflammatory status or increase serum potassium.
conclusionRoxadustat did not differ from ESAs in the treatment of anemia in CKD patients. However, it has the potential to lower blood lipids and improve iron deficiency. CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR2300071087.
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