Evidence map›Paper›PMID 39917922›Full record

ArticleCombinatorial chemistry & high throughput screening2026

Study on the Mechanism of Anti-Atopic Dermatitis by Herba Siegesbeckiae Based on Metabolomics.

YingYue Wang, Xiaowei Chen, Lingling Zhang, Yuting Chen, Yubin Xu, Chunxue You, Xuetao Lu

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Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

YingYue WangTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Xiqing District, Tianjin 300384, China.
Xiaowei ChenTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Xiqing District, Tianjin 300384, China.
Lingling ZhangDepartment of Pharmacy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.
Yuting ChenDepartment of Pharmacy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.
Yubin XuDepartment of Pharmacy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.
Chunxue YouTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Xiqing District, Tianjin 300384, China.
Xuetao LuDepartment of Dermatology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.

Funding

National Natural Science Foundation of China 81803681University Medical Special Scientific Research Project of Taizhou University G2023FSXY03Zhejiang Province Traditional Chinese Medicine Science and Technology Project 2024030145
6 · The paper itself

Abstract

backgroundAtopic dermatitis is a common inflammatory skin disease worldwide that is characterized by skin barrier dysfunction, itching, and a reduced quality of life.

objectiveThe research at hand aimed to delve into the anti-atopic dermatitis mechanism of Herba Siegesbeckiae, a traditional medicinal herb, using a metabolomic approach.

methodsThe molecular mechanism by which Herba Siegesbeckiae acts against atopic dermatitis was investigated by establishing a mouse model of atopic dermatitis while conducting a metabolomics analysis on its metabolites.

resultsInterleukin IL-13, IL-17A, IL-3, IL-31, IL-33, IL4, IL-5, TSLP, IgE, and histamine levels in serum, participating in inhibiting itching and regulating immunity signaling were found to be restored to varying degrees in AD treating with HS. A total of 31 differential metabolites were selected from metabolomics results, among which N-acetyl-L-alanine (VIP = 1.62), Nacetyl- L-methionine (VIP = 1.5), uracil (VIP = 1.47), and prostaglandin E2 (VIP = 1.4) play important roles in the anti-AD regulatory mechanisms of HS and can be used as biomarkers. In addition, the mechanisms of HS anti-AD have been shown to be associated with seven metabolic pathways, including β-alanine metabolism, glycerophospholipid metabolism, histidine metabolism, and so on.

conclusionIn conclusion, HS demonstrated properties that counteract Atopic Dermatitis by suppressing itchiness and boosting the immune system, subsequently controlling the concentrations of related metabolites.

Indexed as

AsteraceaeDermatitis, AtopicMetabolomicsAnimalsCytokinesDisease Models, AnimalMiceMice, Inbred BALB CCytokinesAtopic dermatitisherba siegesbeckiaemechanismmetabolomicstraditional chinese medicine.

Identifiers

PMID39917922

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