ArticleRecent advances in inflammation & allergy drug discovery2025
An Assessment of BHLHE40 Transcription Factor Level and its Target Cytokines in Patients with Rheumatoid Arthritis.
Article in Recent advances in inflammation & allergy drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionBasic helix-loop-helix protein 40 (BHLHE40) can function as both a transcriptional activator and repressor. Recent studies have reported its regulatory functions in T helper (Th)1 and Th17 immune responses. Rheumatoid arthritis (RA) is an autoimmune inflammatory disease in which joints are involved. Both Th1 and Th17 contribute to the pathogenesis of the disease. In the present study, the levels of BHLHE40, interleukin 17
methodsTwo groups, including RA patients and healthy individuals, were included in the study. The relative expression levels of BHLHE40, IL-17, and IFN-γ were quantified in peripheral blood mononuclear cells (PBMCs) using real-time PCR.
resultsThe results showed that the level of DISCUSSION: Given the rapid pace of research showing the importance of Bhlhe40 in anti-tumor, anti-pathogen, and autoimmune responses, it is anticipated that Bhlhe40 might be leveraged either as a putative biomarker or as a candidate target for therapy in a variety of human diseases.
conclusionEvaluation of the expression level of
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