Evidence map›Paper›PMID 39917760›Full record

ArticleNeuro-oncology practice2025

Illness understanding and religiousness in patients with recurrent glioblastoma.

John T Fortunato, Leah E Walsh, Laura C Polacek, Anne S Reiner, Tobias Walbert, Alissa A Thomas, Justin Buthorn, Allison Sigler, Holly G Prigerson, Allison J Applebaum and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02375841 (Coping With Glioblastoma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02375841 active not recruitingnot on this map

Coping With Glioblastoma: A Study of Communication Between Physicians, Patients, and Caregivers

TypeobservationalSponsorMemorial Sloan Kettering Cancer CenterRan2015 to 2027Enrolled309ConditionsBrain Cancer, GlioblastomaArmspsychometric tests, questionnaires and neurocognitive assessments
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John T FortunatoDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-9979-2444
Leah E WalshDepartment of Psychology, Fordham University, Bronx, New York, USA.
Laura C PolacekDepartment of Psychology, Fordham University, Bronx, New York, USA.
Anne S ReinerDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-1258-6112
Tobias WalbertDepartment of Neurosurgery and Neurology, Henry Ford Health, Wayne State and Michigan State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0003-0667-8106
Alissa A ThomasDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Justin ButhornDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Allison SiglerDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Holly G PrigersonCornell Center for Research on End of Life Care, Department of Radiology and Medicine, Weill Cornell Medicine, New York, New York, USA.
Allison J ApplebaumDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Eli L DiamondDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-5456-5961

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background: Patients with glioblastoma (GBM) often have inaccurate perceptions of prognosis. Strong religious beliefs have been associated with limited illness understanding (IU) in patients with advanced cancer, but IU and religiousness have not been investigated in patients with GBM. The aim of this study was to evaluate the association between religiousness and spirituality and IU in patients with GBM. Methods: Patients enrolled in a prospective multicenter study of recurrent GBM (Coping with Glioblastoma, NCT02375841). Within one month of medical visits discussing MRI scans showing GBM progression, patients completed study surveys containing published measures of IU and religiousness. IU was compared between participants with moderate or high versus slight or no religiousness based on several patient-reported prompts using Fisher's exact tests. Results: Twenty-four patients completed surveys of religiousness and IU. IU was partial within our cohort. Fifteen participants (62.5%) acknowledged that their illness was terminal. Only 6 (25%) correctly acknowledged their prognosis (months). Eleven patients (46%) were moderately or very religious, while 9 (38%) were either slightly religious or not at all religious. High religiousness and spirituality were each associated with partial IU ( Conclusions: This prospective study that suggests religiousness, including the belief in miracles and a belief in sanctification through suffering, might influence patients' IU. Further research is warranted to study this association.

Indexed as

end-of-lifeethicsglioblastomaprognosisreligiousness

Identifiers

PMID39917760
PMCPMC11798605

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.