Evidence map›Paper›PMID 39917758›Full record

ArticleNeuro-oncology practice2025

Pediatric metastatic extracranial high-grade glioma: A case report and literature review.

Naba Ali, Bree R Eaton, Jason R Fangusaro, Robert C Castellino, José E Velázquez Vega, Joshua J Chern, Matthew Schniederjan, Prabhumallikarjun Patil

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naba AliWinship Cancer Institute, Emory University, Atlanta, Georgia, USA (N.A., B.R.E.).ORCID https://orcid.org/0000-0002-6297-9192
Bree R EatonAflac Cancer Center and the Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA (J.R.F., R.C.C., J.E.V., J.J.C., M.S.).
Jason R FangusaroAflac Cancer Center and the Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA (J.R.F., R.C.C., J.E.V., J.J.C., M.S.).
Robert C CastellinoAflac Cancer Center and the Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA (J.R.F., R.C.C., J.E.V., J.J.C., M.S.).
José E Velázquez VegaAflac Cancer Center and the Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA (J.R.F., R.C.C., J.E.V., J.J.C., M.S.).
Joshua J ChernAflac Cancer Center and the Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA (J.R.F., R.C.C., J.E.V., J.J.C., M.S.).
Matthew SchniederjanAflac Cancer Center and the Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA (J.R.F., R.C.C., J.E.V., J.J.C., M.S.).
Prabhumallikarjun Patil

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a 10-year-old male with a right frontal diffuse pediatric-type high-grade glioma (HGG), H3-wild-type (WT), and IDH-WT, diagnosed at the age of 9 years, who underwent gross total resection, 60 Gy focal proton radiation in 30 fractions to the resection cavity with concurrent temozolomide followed by maintenance chemotherapy with temozolomide and lomustine. One month after completion of maintenance chemotherapy, he developed subcutaneous swelling in the right temporal region and was treated with antibiotics for presumed lymphadenitis. Two months later, he developed a recurrent painless right parietal soft tissue mass that failed to respond to antibiotic therapy. This prompted evaluation by MRI which revealed new enhancing masses in the cerebellum and extracranial soft tissue mass in the right temporal region. He underwent gross total resection of both masses. Pathologic analysis confirmed both masses as recurrent HGG. Molecular markers, however, differed between the 2 sites of recurrence. He proceeded to complete hypofractionated proton therapy at sites of recurrence. Three months later, he was found to have tumor dissemination into the spine and brain for which he received proton therapy to the whole spine and brain. Due to the presence of

Indexed as

extracranial metastasismolecular markerspediatric high-grade gliomapediatric neuro-oncologytargeted therapy

Identifiers

PMID39917758
PMCPMC11798610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.