Association between microsatellite polymorphism in the Heme Oxygenase-1 (HMOX1) gene promoter and type 2 diabetes: an updated meta-analysis.

Juan José Rivera-Valdés, Sonia Sifuentes-Franco, Sandra Margarita Ramírez-Meza, Omar Íñiguez-Mosqueda, José Javier Morales-Núñez, Mayra Leticia Ramírez-Evangelista, Itzel Viridiana Reyes-Pérez, Omar Graciano-Machuca

Abstract readReview

PubMed Full text at PMC Publisher

In one paragraph

Review in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome.Frontiers in endocrinology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan José Rivera-Valdés *Institute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, 44340 Guadalajara, Jalisco Mexico.

Sonia Sifuentes-Franco *Clinical Science Laboratory, Department of Health Sciences, Los Valles Campus, University of Guadalajara, 46600 Ameca, Jalisco Mexico.

Sandra Margarita Ramírez-MezaLaboratory for the Evaluation of Nutritional Status and Dietetics, Department of Health Sciences, Los Valles Campus, University of Guadalajara, 46600 Ameca, Jalisco Mexico.

Omar Íñiguez-MosquedaInternal Medicine Service, Nuevo Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", 44340 Guadalajara, Jalisco Mexico.

José Javier Morales-NúñezClinical Science Laboratory, Department of Health Sciences, Los Valles Campus, University of Guadalajara, 46600 Ameca, Jalisco Mexico.

Mayra Leticia Ramírez-EvangelistaClinical Science Laboratory, Department of Health Sciences, Los Valles Campus, University of Guadalajara, 46600 Ameca, Jalisco Mexico.

Itzel Viridiana Reyes-PérezDepartment of Molecular Biology and Genomics, University Center for Health Science, University of Guadalajara, 44340 Guadalajara, Jalisco Mexico.

Omar Graciano-MachucaLaboratory of Biological Systems, University of Guadalajara, Los Valles Campus, 46600 Ameca, Jalisco Mexico.ORCID 0000-0002-2328-796X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over a decade has passed since the first meta-analysis examining (GT)n repeats in the Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01575-y.

Indexed as

Heme oxygenase 1HMOX1MicrosatelliteOxidative stressType 2 diabetes

Identifiers

PMID39917725

DOI10.1007/s40200-025-01575-y

PMCPMC11794720

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.