ArticleFrontiers in dental medicine2024
Variability of salivary analytes under daily conditions and their implications for periodontitis biomarkers.
Article in Frontiers in dental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Saliva as a Matrix for Primary Care: Feasibility and Scoping of Its Use for Assessment of Nutrition and Inflammation.Advances in nutrition (Bethesda, Md.) · 2026Review
- The inflammation-pyroptosis axis links local and systemic biomarker profiles to active alveolar bone microstructural deterioration.Frontiers in physiology · 2026Article
- Leveraging Dental Biotechnology for Population Oral Health: Innovations in Prevention, Diagnosis, and Treatment.International journal of molecular sciences · 2025Review
- Article
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Authors and funding
7 authors.
Funding
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Abstract
Introduction: Recent studies have identified inflammatory mediators as potential biomarkers for monitoring or diagnosing periodontitis. However, the brief half-life of these mediators, coupled with their variability among different individuals and across different stages of periodontal disease, may limit their reliability as biomarkers. Methods: In this study, we assessed the concentration profile of salivary biomarkers (IL-6, IL-8, and total protein) through repeated measurements within the same day and across different days in 79 patients exhibiting various states of periodontal health: intact periodontium, stable periodontitis, and active periodontitis. Additionally, we explored how daily variations, such as the interval between toothbrushing and eating, impact the levels of these salivary biomarkers and their diagnostic efficacy for periodontitis activity. Results: Our results showed high salivary levels of IL-6 and total proteins in periodontitis patients ( Conclusions: Our study demonstrated consistency in the repeated measurements of salivary analytes, both within the same day and across different days, except for salivary total protein levels. These analytes exhibited variability within a range that did not undermine their effectiveness as biomarkers for periodontal disease.
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