Evidence map›Paper›PMID 39917652›Full record

ReviewFrontiers in dental medicine2024

Nanoparticle-based biomolecules in cancer diagnosis, therapy, drug delivery and prognosis.

Sowmya Sv, Dominic Augustine, Jagdish Hosmani, Francesco Pagnoni, Rodolfo Reda, Luca Testarelli, Shankargouda Patil

Abstract readReview
In one paragraph

Review in Frontiers in dental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sowmya SvDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, India.
Dominic AugustineDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, India.
Jagdish HosmaniDepartment of Diagnostic Dental Sciences, Oral Pathology Section, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Francesco PagnoniDepartment of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, Italy.
Rodolfo RedaDepartment of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, Italy.
Luca TestarelliDepartment of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, Italy.
Shankargouda PatilCollege of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Nanoparticles have orchestrated a paradigm shift in the landscape of cancer diagnosis and therapy, presenting a multifaceted approach to tackle the intricacies of malignancies. This comprehensive exposition delves deep into the forefront of nanomedicine, elucidating pivotal strategies and innovations primed to metamorphose the domain of cancer management. Methodology: Nanoparticles transcend traditional boundaries, enabling meticulous, site-specific drug release while minimizing systemic toxicity. Intricately designed activation mechanisms, encompassing pH and enzymatic responsivity, along with concentration-dependent strategies, exploit the distinctive attributes of cancer cells, heralding an era characterized by unprecedented therapeutic precision. The pervasive influence of nanotechnology extends to diagnostics, unlocking the realm of early disease detection and personalized treatment. These versatile agents bestow empowering capabilities upon sensitive imaging modalities, affording real-time monitoring and theranostic potential. Results: This exposition showcases the evolution of cutting-edge nanoplatforms, bridging the chasm between diagnosis and therapy, thereby redefining the confines of cancer care. This review elucidates strategies to combat drug resistance, a perennial challenge within cancer management. By targeting efflux transporters, modulating apoptotic pathways, and countering hypoxia-induced resistance, nanoparticles stand at the vanguard of therapeutic innovation, poised to reinvigorate treatment efficacy. Discussion & Conclusion: Moreover, this exposé underscores the imminent clinical translation of nanoparticle-based drugs, accentuating their potential to metamorphose the landscape of cancer management. Liposomal vaccines, nano-pharmaceuticals, and nanochemodrugs, currently navigating the crucible of clinical trials, bear immense promise in advancing the realm of precision medicine. In this epoch of precision medicine, nanoparticle-fueled innovations stand poised to propel cancer diagnosis and therapy to unprecedented peaks.

Indexed as

cancer diagnosiscancer therapyliposomal vaccinesnanochemodrugsnanoparticlesnano-pharmaceuticalsprognosis

Identifiers

PMID39917652
PMCPMC11797830

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.