Evidence map›Paper›PMID 39917636›Full record

ArticleEuropean journal of anaesthesiology and intensive care2024

Determination of positive end-expiratory pressure in COVID-19-related acute respiratory distress syndrome: A systematic review.

Alexandra Sachkova, Marike Andreas, Daniel Heise, Martin Golinski, Caspar Stephani, Steffen Dickel, Clemens Grimm, Ina Monsef, Vanessa Piechotta, Nicole Skoetz and 2 more

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In one paragraph

Article in European journal of anaesthesiology and intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra SachkovaFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Marike AndreasFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Daniel HeiseFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Martin GolinskiFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Caspar StephaniFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Steffen DickelFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Clemens GrimmFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Ina MonsefFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Vanessa PiechottaFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Nicole SkoetzFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Sven LaudiFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).
Onnen MoererFrom the Department of Anesthesiology, University Medical Center Göttingen, Göttingen (AS, DH, MG, CS, SD, CG, OM), Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne (IM, VP, NS), Department of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig (SL) and Center for Preventive Medicine and Digital Health (CPD), Division of Public Health, Social and Preventive Medicine, Universitätsmedizin Mannheim Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer, Mannheim, Germany (MA).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of high positive end-expiratory pressure (PEEP) ventilation and the optimization of PEEP titration in COVID-19-induced acute respiratory distress syndrome (ARDS) continues to be a subject of debate. In this systematic review, we investigated the effects of varying PEEP settings on patients with severe ARDS primarily resulting from COVID-19 (C-ARDS).

objectivesDoes higher or lower PEEP improve the outcomes in COVID-19 ARDS? Does individually titrated PEEP lead to better outcomes compared with PEEP set by standardised (low and high ARDS network PEEP tables) approaches? Does the individually set PEEP (best PEEP) differ from PEEP set according to the standardised approaches (low and high ARDS network PEEP tables)?

designSystematic review of observational studies without metaanalysis. DATA SOURCES: We performed an extensive systematic literature search in Cochrane COVID-19 Study Register (CCSR), PubMed, Embase.com, Web of Science Core Collection, World Health Organization COVID-19 Global literature on coronavirus disease, World Health Organization International Clinical Trials Registry Platform (ICTRP), medRxiv, Cochrane Central Register of Controlled Trials until 24/01/2024. ELIGIBILITY CRITERIA: Ventilated adult patients (≧18 years) with C-ARDS.

resultsWe screened 16 026 records, evaluated 119 full texts, and included 12 studies (

conclusionThe available evidence does not provide sufficient guidance for recommendations on optimal PEEP settings in C-ARDS. In general, well designed platform studies are needed to answer the questions raised in this review and, in particular, to investigate the use of individualised PEEP titration techniques and the inclusion of patients with different ARDS entities, severities and disease stages. TITLE REGISTRATION: Our systematic review protocol was registered with the international prospective register of systematic reviews (PROSPERO 2021: CRD42021260303).

Identifiers

PMID39917636
PMCPMC11798381

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.