Evidence map›Paper›PMID 39917593›Full record

ArticleEuropean journal of anaesthesiology and intensive care2023

The comparison of caesarean section bleeding between volatile and total intravenous anaesthesia in a Japanese nationwide database.

Kensuke Shimada, Masao Iwagami, Kanako Makito, Daisuke Shigemi, Kazuaki Uda, Miho Ishimaru, Jun Komiyama, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi and 3 more

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Article in European journal of anaesthesiology and intensive care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Kensuke ShimadaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Masao IwagamiFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Kanako MakitoFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Daisuke ShigemiFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Kazuaki UdaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Miho IshimaruFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Jun KomiyamaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Kojiro MoritaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Hiroki MatsuiFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Kiyohide FushimiFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Hideo YasunagaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Makoto TanakaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).
Nanako TamiyaFrom the Graduate School of Comprehensive Human Sciences (KS, JK), Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki (MIw, KU, JK, NT), Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo (KMa, DS, HM, HY), Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (MIs), Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo (KMo), Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo (KF) and Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (MT).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVolatile anaesthesia may increase blood loss because of the uterine-relaxing effect of the volatile anaesthetics during caesarean section under general anaesthesia.

objectiveThis study compared the bleeding risk during caesarean section between volatile anaesthesia and total intravenous anaesthesia (TIVA) using a nationwide inpatient database in Japan.

designObservational study.

settingNationwide inpatient database in Japan from April 2012 to March 2020. PATIENTS: Women who underwent caesarean section under general anaesthesia.

main outcome measuresVolume of blood loss.

resultsWe identified 26 585 women, including 19 320 in the volatile anaesthesia group (mean age = 32.9 ± 5.5 years) and 7265 in the TIVA group (mean age = 32.8 ± 5.5 years). The mean blood loss was 1113 ± 909 and 1136 ± 944 ml and the proportion of blood transfusion was 14.7 and 16.0% in the volatile and TIVA groups, respectively. With conventional regression analyses, volatile anaesthesia was associated with a slightly lower risk of bleeding: the adjusted mean difference for blood loss (95% CI) was -56.1 (-81.4 to -30.7). However, in the instrumental variable analysis, volatile anaesthesia was associated with a higher risk of bleeding: adjusted mean difference for blood loss (95% CI) was 154.3 (112.4 to 196.3) ml.

conclusionThis large observational study with instrumental variable analyses suggested an increased bleeding risk associated with volatile anaesthesia, and the results were not identical to those in the conventional regression analyses.

Identifiers

PMID39917593
PMCPMC11783640

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