Evidence map›Paper›PMID 39917442›Full record

ArticleEuropean journal of anaesthesiology and intensive care2024

The use of tier three therapies in acute brain injured patients: Insight from the Extubation strategies in Neuro-Intensive care unit patients and associations with Outcomes observational study.

Carolina Iaquaniello, Fabio Gallo, Raphael Cinotti, Giuseppe Citerio, Fabio S Taccone, Paolo Pelosi, Rafael Badenes, Chiara Robba

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In one paragraph

Article in European journal of anaesthesiology and intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolina IaquanielloFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Fabio GalloFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Raphael CinottiFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Giuseppe CiterioFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Fabio S TacconeFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Paolo PelosiFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Rafael BadenesFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).
Chiara RobbaFrom the Neurointensive care and Anesthesia, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (CI), Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy (FG), Department of Anaesthesia and Critical Care, CHU Nantes, Nantes Université, Hôtel Dieu, Nantes, France (RC), School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy (GC), Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium (FST), IRCCS Ospedale Policlinico San Martino (PP, CR), Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università di Genova, Genova, Italy (PP, CR) and Department of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain (RB).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with acute brain injury (ABI) and refractory intracranial hypertension, the so-called 'tier three therapies' (TTT) (hypothermia, metabolic suppression with barbiturates, and decompressive craniectomy) may be used.

objectiveWe aimed to describe the incidence of use of TTT, and to assess their effect on outcome.

designA secondary analysis of the ENIO observational study.

settingSeventy-three intensive care units (ICUs) in 18 countries worldwide between June 2018 and November 2020. PATIENTS: One thousand five hundred and twelve adult patients admitted to an intensive care unit (ICU) with ABI were included and categorised according to use or not of one or more TTT.

resultsThree hundred and ninety-six patients (26.2%) received at least one TTT during the ICU stay. Five patients (0.3%) received all three TTT. TTT patients were younger (

conclusionPatients with ABI are frequently managed using at least one TTT. Their use varies according to a country's economic resources, the type of ABI, and ICP monitoring and is associated with a higher risk of complications but not with ICU or hospital mortality.

Identifiers

PMID39917442
PMCPMC11798370

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