ArticleFrontiers in neurology2024
Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Risk of epilepsy in people with adult-onset hydrocephalus: insights from the UK Biobank.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The Saga of Late-Onset Unexplained Epilepsy.Epilepsy currents · 2026Review
- Brain Structural Changes and Cognitive-Clinical Profiles in Late-Onset Unexplained Epilepsy.Neurology · 2026Article
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Authors and funding
6 authors.
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Abstract
Objective: The cause of late-onset first epileptic seizures (LOFES) in older age is often not readily evident. In absence of probable causes, it has been suggested that cerebral small vessel disease (CSVD), which is common with increasing age, may be crucial. We aimed to further investigate the impact of white matter lesion (WML) burden and distribution pattern on LOFES. Methods: We retrospectively compared structural MRI of LOFES patients ( Results: Comparing intrapersonal volume ratios adjusted for the effects of gender and age, we found that the WML distribution was shifted to the juxtacortical compartment in LOFES patients. Among several influencing variables a path analysis could additionally show that this juxtacortical weighting of WML was a significant predictor for LOFES ( Significance: By using algorithm-based automated lesion segmentation software tools and VBM analysis we could highlight that a juxtacortical weighting of WML distribution and regionally decreased gray matter volume distinguished LOFES from TIA and PC groups in our sample.
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