Evidence map›Paper›PMID 39917370›Full record

ArticleEuropean journal of anaesthesiology and intensive care2022

The influence of haemorrhagic shock on the pharmacokinetic and pharmacodynamic effects of remimazolam in a swine model: A laboratory study.

Tadayoshi Kurita, Shingo Kawashima, Mohamed Mathar Sahib Ibrahim Khaleelullah, Koji Morita, Yuko Kurosawa, Takafumi Naito, Yoshiki Nakajima

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In one paragraph

Article in European journal of anaesthesiology and intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tadayoshi KuritaFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).
Shingo KawashimaFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).
Mohamed Mathar Sahib Ibrahim KhaleelullahFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).
Koji MoritaFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).
Yuko KurosawaFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).
Takafumi NaitoFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).
Yoshiki NakajimaFrom the Department of Anesthesiology and Intensive Care (T-K, S-K, MMSI-K, K-M, Y-N), Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan (Y-K, T-N).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHaemorrhagic shock enhances the potency of several intravenous anaesthetics.

objectiveTo assess the influence of haemorrhagic shock on the pharmacokinetic and pharmacodynamic effects of remimazolam, a new short-acting benzodiazepine.

designAn animal observational study.

settingAn animal laboratory in Hamamatsu University School of Medicine, Hamamatsu, Japan, from 3 April to 7 June 2021. ANIMALS: Ten pigs, 24.5 ± 0.5 (mean ± standard deviation) kg.

interventionsPigs were anaesthetised with isoflurane, and raw electroencephalographic waveforms, bispectral index (BIS) and 95% spectral edge frequency (SEF) were recorded throughout the study. After isoflurane was stopped, remimazolam was administered at a rate of 150 mg h

main outcome measuresPharmacokinetic variables were quantified using a three-compartment model and the pharmacodynamic variables were estimated using an inhibitory sigmoid maximal effect model.

resultsThe peak remimazolam concentration increased from 1.0 ± 0.3 to 1.5 ± 0.4 μg ml

conclusionHaemorrhagic shock alters the pharmacokinetics of remimazolam, but does not enhance the end-organ sensitivity. Because the impact of haemorrhagic shock is small, remimazolam might be a suitable sedative/hypnotic for the management of patients who have massive bleeding.

Identifiers

PMID39917370
PMCPMC11783651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.