ArticleOpen forum infectious diseases2025
Adenovirus Infections and Disease in Solid Organ Transplant Recipients: Incidence and Outcomes.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
11 authors.
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Abstract
Background: We aimed to examine the epidemiology and outcomes of AdV disease in SOTr and assess the utility of AdV surveillance in SOTr <13 years. Methods: SOTr transplanted at Rigshospitalet, 2010-2021, were included. The center had a screening program for SOTr <13 years with monthly plasma AdV tests the first 6 months following transplantation. Results: We included 2009 SOTr (of whom 82 were aged <13 years), and 1330 blood samples from 382 SOTr were analyzed for AdV, of which 10 (0.8%) from 6 SOTr <13 years tested positive. Five out of six were tested as part of the screening program. Three remained asymptomatic, while three had symptoms attributable to co-infections. One adult lung transplant recipient with AdV in BAL had acute exacerbation of chronic graft rejection. Conclusions: We found a low incidence of AdV disease. SOTr diagnosed with AdV viremia as part of screening remained asymptomatic or had symptoms attributable to co-infections. Our findings do not support routine surveillance for AdV in SOTr.
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