Evidence map›Paper›PMID 39917332›Full record

ArticleOpen forum infectious diseases2025

Detection of Pneumococcal Carriage in Asymptomatic Healthcare Workers.

Pari Waghela, Raechel Davis, Melissa Campbell, Rupak Datta, Maikel S Hislop, Noel J Vega, Loren Wurst, Devyn Yolda-Carr, Luke Couch, Michael Hernandez and 7 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. An abundance ofMicrobiology (Reading, England) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pari WaghelaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Raechel DavisDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Melissa CampbellDivision of Pediatric Infectious Diseases, Department of Pediatrics, Duke University School of Medicine, Duke University, Durham, North Carolina, USA.
Rupak DattaDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-2281-7508
Maikel S HislopDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Noel J VegaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Loren WurstDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Devyn Yolda-CarrDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Luke CouchDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Michael HernandezDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Lindsay R GrantGlobal Respiratory Vaccines, Pfizer, Inc., Collegeville, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4538-6424
Ronika Alexander-ParrishGlobal Respiratory Vaccines, Pfizer, Inc., Collegeville, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0932-7467
Adriano ArguedasGlobal Respiratory Vaccines, Pfizer, Inc., Collegeville, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1659-8225
Bradford D GessnerGlobal Respiratory Vaccines, Pfizer, Inc., Collegeville, Pennsylvania, USA.
Richard A MartinelloDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-0355-9200
Daniel M WeinbergerDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-1178-8086
Anne L WyllieDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-6015-0279

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Background: Healthcare workers are at increased risk of exposure to respiratory pathogens including Methods: We evaluated pneumococcal carriage in convenience samples of saliva, self-collected from asymptomatic healthcare workers (Connecticut, USA) who were testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 30 March to 11 June 2020. DNA extracted from the culture-enriched saliva was later tested using quantitative polymerase chain reaction for Results: Study participants were 22-74 years old (mean age, 38.5 years), 75% female, 75% white, and with occupations including registered nurses (48%), medical doctors (23%), and patient care assistants (5%). Overall, 138 of 1241 samples (11%) from 86 of 392 individuals (21%) tested Conclusions: During a period of mandatory masking, we identified a cumulative pneumococcal carriage prevalence of 21% among healthcare workers. This study highlights that healthcare workers may act as unrecognized reservoirs of pneumococcus in the population. Despite long-standing pediatric immunization programs, vaccine-targeted serotypes continue to be prevalent among the adult population.

Indexed as

carriagepandemicpneumococcussalivasurveillance

Identifiers

PMID39917332
PMCPMC11800483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.