Evidence map›Paper›PMID 39917306›Full record

ArticleFrontiers in immunology2025

Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database.

Wenquan Ding, Rui La, Shenghao Wang, Zhiyuan He, Dinghua Jiang, Zhigang Zhang, Hao Ni, Wu Xu, Lixin Huang, Qian Wu

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  4. Synovial Fluid Biomarkers Reflect Pre- and Postoperative Clinical Features in Rotator Cuff Tears, Independent of Tear Size.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenquan Ding *Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Rui La *Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Shenghao Wang *Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Zhiyuan HeDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Dinghua JiangDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Zhigang ZhangDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Hao NiDepartment of Pathology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Wu XuDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Lixin HuangDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.
Qian WuDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The association between the neutrophil percentage to albumin ratio (NPAR) and the risk of osteoarthritis (OA) and rheumatoid arthritis (RA) remains unclear. This study aims to investigate the association between NPAR and the risk of OA and RA. Methods: This cross-sectional study analyzed data from 92,062 American adults in the NHANES database between 1999 and 2016. Various statistical analyses were conducted to investigate the associations between NPAR and the risks of OA and RA, including multivariable logistic regression, subgroup analysis, smooth curve fitting, and threshold effect analysis. Results: After screening, the final study population included 36,147 participants, with 3,881 individuals diagnosed with OA and 2,178 with RA. After adjusting for confounding factors, higher NPAR levels were associated with an increased risk of RA (OR=1.05; 95% CI: 1.03-1.07; Conclusion: High levels of NPAR is positively associated with the prevalence of RA. This provides us with new insights for the management and treatment of RA patients.

Indexed as

Arthritis, RheumatoidNeutrophilsOsteoarthritisAdultAgedBiomarkersCross-Sectional StudiesDatabases, FactualFemaleHumansLeukocyte CountMaleMiddle AgedNutrition SurveysRisk FactorsUnited StatesBiomarkerscross-sectional studyinflammationNational Health and Nutrition Examination Surveyneutrophil percentage to albumin ratioosteoarthritisrheumatoid arthritis

Identifiers

PMID39917306
PMCPMC11799277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.